Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia. (Q51139133)

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scientific article published on 13 February 2017

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English	Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia.	scientific article published on 13 February 2017

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scholarly article

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Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia (English)

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Andrew Intlekofer

6

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Christopher E. Mason

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Christopher E Mason

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Cem Meydan

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Craig B. Thompson

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Craig B Thompson

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author name string

Alan H Shih

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Kaitlyn Shank

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Francine E Garrett-Bakelman

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Patrick S Ward

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Abbas Nazir

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Eytan M Stein

8

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Kristina Knapp

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Jacob Glass

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Jeremy Travins

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Kim Straley

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Camelia Gliser

13

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Katharine Yen

15

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Ari Melnick

17

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Ross L Levine

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publication date

13 February 2017

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Cancer Discovery

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7

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494-505

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5

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2 April 2020

TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes

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DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

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IDH2 inhibition in AML: Finally progress?

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Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia

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WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation

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DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia

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IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition

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5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.

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TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients

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Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis

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Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition

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Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia

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RNA-dependent inhibition of ribonucleotide reductase is a major pathway for 5-azacytidine activity in acute myeloid leukemia

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TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics

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10 June 2018

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Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

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Adverse impact of IDH1 and IDH2 mutations in primary AML: Experience of the Spanish CETLAM group

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12 December 2020

based on heuristic

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Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias

1 reference

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12 December 2020

based on heuristic

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Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1158/2159-8290.CD-16-1049

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2 April 2020

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2 April 2020

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2 April 2020

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