DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia (Q28253465)

Xinyang Zhao

17

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Valeria Tosello

Valeria Tosello

15

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Omar Abdel-Wahab

Omar Abdel-Wahab

9

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Maria E Figueroa

Maria E Figueroa

33

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Martin S. Tallman

24

Martin S Tallman

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Elisabeth Paietta

27

Elisabeth Paietta

0 references

Christopher E. Mason

30

Christopher E Mason

0 references

Iannis Aifantis

21

Iannis Aifantis

0 references

Craig B. Thompson

28

Craig B Thompson

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author name string

Raajit Rampal

1

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Altuna Alkalin

2

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Jozef Madzo

3

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Aparna Vasanthakumar

4

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Elodie Pronier

5

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Jay Patel

6

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Yushan Li

7

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Jihae Ahn

8

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Alan Shih

10

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Chao Lu

11

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Patrick S Ward

12

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Jennifer J Tsai

13

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Todd Hricik

14

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Danette Daniels

18

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Qing Dai

19

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Luisa Ciminio

20

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Chuan He

22

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Francois Fuks

23

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Adolfo Ferrando

25

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Stephen Nimer

26

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Jonathan D Licht

29

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Lucy A Godley

31

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Ari Melnick

32

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Ross L Levine

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

34

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language of work or name

English

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publication date

11 December 2014

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published in

Cell Reports

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volume

9

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page(s)

1841-55

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issue

5

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cites work

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

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Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models.

29 September 2017

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29 September 2017

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Quantitative DNA methylation predicts survival in adult acute myeloid leukemia

29 September 2017

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An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1.

29 September 2017

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A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16.

29 September 2017

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Tumor suppressor p53 can participate in transcriptional induction of the GADD45 promoter in the absence of direct DNA binding

29 September 2017

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A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1

29 September 2017

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Alternative splicing and genomic structure of the Wilms tumor gene WT1

29 September 2017

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Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing

29 September 2017

1 reference

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Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia.

2 June 2018

1 reference

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The Wilms' tumor gene WT1-GFP knock-in mouse reveals the dynamic regulation of WT1 expression in normal and leukemic hematopoiesis.

27 November 2018

1 reference

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AML1-ETO rapidly induces acute myeloblastic leukemia in cooperation with the Wilms tumor gene, WT1.

27 November 2018

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Overexpression of the Wilms' tumor gene WT1 in de novo lung cancers

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25482556

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutant Wilms' tumor 1 (WT1) mRNA with premature termination codons in acute myeloid leukemia (AML) is sensitive to nonsense-mediated RNA decay (NMD)

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25482556

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Genomic 5-hydroxymethylcytosine levels correlate with TET2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25482556

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2014.11.004

1 reference

3685287

3685287

1 reference

1 reference

1 reference