Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance (Q35234477)

24440599

7 August 2017

title

Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance (English)

1 reference

7 August 2017

1 reference

1

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1 June 2020

Riccardo Taulli

3

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1 June 2020

Rahul Karnik

8

1 reference

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1 June 2020

Pier Paolo Pandolfi

14

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1 June 2020

5

Kerri Burgess

1 reference

1 June 2020

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2

Markus Reschke

1 reference

1 June 2020

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Olga Pozdnyakova

4

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1 June 2020

Parul Bhargava

6

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1 June 2020

Kimberly Straley

7

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1 June 2020

Donald Small

10

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1 June 2020

Shinsan M Su

11

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1 June 2020

Katharine Yen

12

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1 June 2020

Jiangwen Zhang

13

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1 June 2020

Alexander Meissner

9

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1 June 2020

language of work or name

English

0 references

publication date

16 January 2014

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7 August 2017

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1 June 2020

volume

14

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1 June 2020

issue

3

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1 June 2020

page(s)

329-341

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describes a project that uses

1 June 2020

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/4380188

based on heuristic

inferred from PubMed Central ID database lookup

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Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

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(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible

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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

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IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

13 July 2018

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13 July 2018

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

13 July 2018

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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380188

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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13 July 2018

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Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

26 September 2018

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1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24440599

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.STEM.2013.12.016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24440599%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24440599%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

24440599

1 reference

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