Screening out irrelevant cell-based models of disease. (Q50479880)

14 March 2018

review article

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title

Screening out irrelevant cell-based models of disease. (English)

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14 March 2018

author

María C Montoya

7

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14 March 2018

Päivi Östling

8

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14 March 2018

Spencer Shorte

11

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14 March 2018

Daniel Ebner

Daniel Ebner

6

0 references

Neil O Carragher

Neil O Carragher

14

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Leo S. Price

Leo S Price

10

0 references

Marc Bickle

3

Marc Bickle

1 reference

14 March 2018

author name string

Peter Horvath

1

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14 March 2018

Nathalie Aulner

2

1 reference

14 March 2018

Anthony M Davies

4

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14 March 2018

Elaine Del Nery

5

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14 March 2018

Vilja Pietiäinen

9

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14 March 2018

Gerardo Turcatti

12

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14 March 2018

Carina von Schantz

13

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14 March 2018

publication date

12 September 2016

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14 March 2018

Nature Reviews Drug Discovery

published in

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14 March 2018

volume

15

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14 March 2018

page(s)

751-769

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14 March 2018

issue

11

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14 March 2018

https://scigraph.springernature.com/pub.10.1038/nrd.2016.175

exact match

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31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

BioImageXD: an open, general-purpose and high-throughput image-processing platform.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Ultra high content image analysis and phenotype profiling of 3D cultured micro-tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Systems pharmacology: network analysis to identify multiscale mechanisms of drug action

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Distinctive Behaviors of Druggable Proteins in Cellular Networks

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

canSAR: updated cancer research and drug discovery knowledgebase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Computation as the mechanistic bridge between precision medicine and systems therapeutics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Medusa: A tool for exploring and clustering biological networks

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Systematic identification of genomic markers of drug sensitivity in cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Inconsistency in large pharmacogenomic studies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Pharmacogenomic agreement between two cancer cell line data sets.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Enhancing reproducibility in cancer drug screening: how do we move forward?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Developing predictive assays: the phenotypic screening "rule of 3".

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Development of a quantitative 96-well method to image glycogen storage in primary rat hepatocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Accurate prediction of drug-induced liver injury using stem cell-derived populations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Psoriasin (S100A7) associates with integrin β6 subunit and is required for αvβ6-dependent carcinoma cell invasion.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Therapeutic targeting of integrin αvβ6 in breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Preclinical target validation using patient-derived cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

A novel multiple-stage antimalarial agent that inhibits protein synthesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

An image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophages

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Can laboratory reference strains mirror "real-world" pathogenesis?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Bacterial quorum sensing in pathogenic relationships

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

The distributed genome hypothesis as a rubric for understanding evolution in situ during chronic bacterial biofilm infectious processes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Chemical genetics of Plasmodium falciparum

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Integration of chemical and RNAi multiparametric profiles identifies triggers of intracellular mycobacterial killing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Culture of skin cells in 3D rather than 2D improves their ability to survive exposure to cytotoxic agents.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Micro 3D cell culture systems for cellular behavior studies: Culture matrices, devices, substrates, and in-situ sensing methods

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Microfluidic 3D cell culture: from tools to tissue models

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

From 3D cell culture to organs-on-chips

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

The third dimension bridges the gap between cell culture and live tissue

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Drug Discovery Goes Three-Dimensional: Goodbye to Flat High-Throughput Screening?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Three-Dimensional Cell Culture Assays: Are They More Predictive of In Vivo Efficacy than 2D Monolayer Cell-Based Assays?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Bioprinting for cancer research.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

3D bioprinting of tissues and organs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Three-dimensional organotypic culture: experimental models of mammalian biology and disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Life in 3D is never flat: 3D models to optimise drug delivery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Constructive remodeling of a synthetic endothelial extracellular matrix

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

A review of microfabrication and hydrogel engineering for micro-organs on chips

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Synthetic 3D multicellular systems for drug development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Materials science. Hydrogel cell cultures.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Peptide Hydrogels - Versatile Matrices for 3D Cell Culture in Cancer Medicine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Cell adhesion on an artificial extracellular matrix using aptamer-functionalized PEG hydrogels

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Three-dimensional tissue culture based on magnetic cell levitation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Nanomagnetic levitation three-dimensional cultures of breast and colorectal cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Microfluidic compartmentalized co-culture platform for CNS axon myelination research

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

How were new medicines discovered?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Phenotypic screening in cancer drug discovery - past, present and future

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

The discovery of first-in-class drugs: origins and evolution.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Micro and nano-scale in vitro 3D culture system for cardiac stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

HB-EGF affects astrocyte morphology, proliferation, differentiation, and the expression of intermediate filament proteins.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Designing cell-compatible hydrogels for biomedical applications

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

A microfabricated scaffold induces the spheroid formation of human bone marrow-derived mesenchymal progenitor cells and promotes efficient adipogenic differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Profiling distinct mechanisms of tumour invasion for drug discovery: imaging adhesion, signalling and matrix turnover

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra-cellular matrices on adhesion and invasion of ovarian cancer cells to the omentum

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Microfluidics for cell-based high throughput screening platforms - A review

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Organs-on-chips at the frontiers of drug discovery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Tissue models: a living system on a chip.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.175

Mechanism of Induction: Induced Pluripotent Stem Cells (iPSCs).

31 March 2020

1 reference

12 December 2020

In vitro drug sensitivity of cells from children with leukemia using the MTT assay with improved culture conditions.

1 reference

12 December 2020

Cell culture, oxidative stress, and antioxidants: avoiding pitfalls

1 reference

12 December 2020

Imaging cellular spheroids with a single (selective) plane illumination microscope

1 reference

12 December 2020

Ex vivo therapeutic index by drug sensitivity assay using fresh human normal and tumor cells.

1 reference

12 December 2020

Use of vasoactive agents to increase tumor perfusion and the antitumor efficacy of drug-monoclonal antibody conjugates

1 reference

12 December 2020

Organotypic collagen I assay: a malleable platform to assess cell behaviour in a 3-dimensional context

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD.2016.175

1 reference

14 March 2018

PubMed ID

27616293

1 reference

14 March 2018