BRD4 profiling identifies critical Chronic Lymphocytic Leukemia oncogenic circuits and reveals sensitivity to PLX51107, a novel structurally distinct BET inhibitor. (Q49546562)

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scientific article published on 31 January 2018

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English	BRD4 profiling identifies critical Chronic Lymphocytic Leukemia oncogenic circuits and reveals sensitivity to PLX51107, a novel structurally distinct BET inhibitor.	scientific article published on 31 January 2018

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scholarly article

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21 February 2018

http://europepmc.org/abstract/MED/29386193

BRD4 profiling identifies critical Chronic Lymphocytic Leukemia oncogenic circuits and reveals sensitivity to PLX51107, a novel structurally distinct BET inhibitor. (English)

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http://europepmc.org/abstract/MED/29386193

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chronic lymphocytic leukemia

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based on heuristic

inferred from title

Nicole R Grieselhuber

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Nicole R Grieselhuber

8

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Bonnie K Harrington

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Bonnie Harrington

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Gideon Bollag

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Rafe Shellooe

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Gaston Habets

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John C Byrd

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Ewy A Mathé

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Hatice Gulcin Ozer

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Dalia El-Gamal

2

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Ben Powell

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Zachary A Hing

4

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James S Blachly

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Shaneice Mitchell

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Katie Williams

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Tzung-Huei Lai

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Lapo Alinari

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Robert A Baiocchi

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Lindsey Brinton

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Elizabeth Baskin

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Matthew Cannon

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Larry Beaver

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Virginia M Goettl

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David M Lucas

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Jennifer A Woyach

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Deepa Sampath

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Amy M Lehman

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Lianbo Yu

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Jiazhong Zhang

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Yan Ma

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Ying Zhang

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Wayne Spevak

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Songyuan Shi

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Paul Severson

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Heidi Carias

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Garson Tsang

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Ken Dong

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Todd Ewing

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Adhirai Marimuthu

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Christina Tantoy

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Jason Walters

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Laura Sanftner

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Hamid Rezaei

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Marika Nespi

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Bernice Matusow

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Prabha Ibrahim

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Chao Zhang

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Rosa Lapalombella

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publication date

31 January 2018

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Cancer Discovery

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Europe PubMed Central

21 February 2018

http://europepmc.org/abstract/MED/29386193

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

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HEXIM1 as a Robust Pharmacodynamic Marker for Monitoring Target Engagement of BET Family Bromodomain Inhibitors in Tumors and Surrogate Tissues

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BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members

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Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks

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Lenalidomide Induces Interleukin-21 Production by T Cells and Enhances IL21-Mediated Cytotoxicity in Chronic Lymphocytic Leukemia B Cells.

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Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study

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IL-4 enhances expression and function of surface IgM in CLL cells.

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Active medulloblastoma enhancers reveal subgroup-specific cellular origins

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Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia

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Mutations driving CLL and their evolution in progression and relapse

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Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib

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Etiology of Ibrutinib Therapy Discontinuation and Outcomes in Patients With Chronic Lymphocytic Leukemia

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Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors.

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Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule

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Targeted therapies in CLL: mechanisms of resistance and strategies for management

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miR-155 expression is associated with chemoimmunotherapy outcome and is modulated by Bruton's tyrosine kinase inhibition with Ibrutinib.

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Ibrutinib treatment ameliorates murine chronic graft-versus-host disease

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Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition

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Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas

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Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors

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The mechanisms behind the therapeutic activity of BET bromodomain inhibition

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Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia

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Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib

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Validation of ZAP-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia

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Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells.

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Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.

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B cell activation through CD40 and IL4R ligation modulates the response of chronic lymphocytic leukaemia cells to BAFF and APRIL.

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Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

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The microenvironment in chronic lymphocytic leukemia (CLL) and other B cell malignancies: insight into disease biology and new targeted therapies

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BET bromodomains mediate transcriptional pause release in heart failure

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Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes

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Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia

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Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia

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Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA

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Chronic lymphocytic leukaemia--the role of the microenvironment pathogenesis and therapy

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Selective inhibition of tumor oncogenes by disruption of super-enhancers

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Understanding the immunodeficiency in chronic lymphocytic leukemia: potential clinical implications

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Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells

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Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

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Transcriptional amplification in tumor cells with elevated c-Myc.

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Bromodomains as therapeutic targets

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

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Selective inhibition of BET bromodomains

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Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

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Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression

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26 August 2018

Expression of TCL-1 as a potential prognostic factor for treatment outcome in B-cell chronic lymphocytic leukemia

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26 August 2018

Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia

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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

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JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model

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26 August 2018

Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882533

26 August 2018

A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882533

26 August 2018

Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882533

26 August 2018

The TCL1 family of oncoproteins: co-activators of transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882533

26 August 2018

Chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882533

26 August 2018

Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882533

26 August 2018

The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882533

26 August 2018

Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882533

26 August 2018

The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882533

26 August 2018

Interleukin-6 and interleukin-10 levels in chronic lymphocytic leukemia: correlation with phenotypic characteristics and outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882533

26 August 2018

bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882533

26 August 2018

Overexpression of cyclin D2 in chronic B-cell malignancies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882533

26 August 2018

Lymphocytic lymphoma/B-chronic lymphocytic leukaemia--an immunohistopathological study of peripheral B lymphocyte neoplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882533

26 August 2018

Non-coding recurrent mutations in chronic lymphocytic leukaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882533

2 November 2018

Overexpression of the chemokine receptor CXCR4 in B cell chronic lymphocytic leukemia is associated with increased functional response to stromal cell-derived factor-1 (SDF-1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/29386193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29386193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development

1 reference

https://pubmed.ncbi.nlm.nih.gov/29386193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCL1 is activated by chromosomal rearrangement or by hypomethylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29386193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression profiling of the functionally distinct human bone marrow stromal cell lines HS-5 and HS-27a

1 reference

https://pubmed.ncbi.nlm.nih.gov/29386193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant expression of TRAIL in B chronic lymphocytic leukemia (B-CLL) cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29386193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state

1 reference

https://pubmed.ncbi.nlm.nih.gov/29386193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-cell-derived mesenchymal stem cells overexpressing Csx/Nkx2.5 and GATA4 undergo the stochastic cardiomyogenic fate and behave like transient amplifying cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29386193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IKZF3 (Aiolos) transcription factor is highly upregulated and inversely correlated with clinical progression in chronic lymphocytic leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/29386193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/2159-8290.CD-17-0902

1 reference

Europe PubMed Central

21 February 2018

http://europepmc.org/abstract/MED/29386193

0 references

1 reference

Europe PubMed Central

21 February 2018

http://europepmc.org/abstract/MED/29386193

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