N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation. (Q48636044)

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scientific article published on 28 March 2012

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English	N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation.	scientific article published on 28 March 2012

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scholarly article

1 reference

Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/22375951

N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation. (English)

1 reference

Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/22375951

long-term potentiation

1 reference

based on heuristic

inferred from title

3

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Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/22375951

author name string

Dagmar Schlenzig

1

1 reference

Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/22375951

Raik Rönicke

2

1 reference

Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/22375951

Hans-Henning Ludwig

4

1 reference

Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/22375951

Eike Scheel

5

1 reference

Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/22375951

Klaus Reymann

6

1 reference

Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/22375951

Takaomi Saido

7

1 reference

Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/22375951

Gerd Hause

8

1 reference

Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/22375951

Stephan Schilling

9

1 reference

Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/22375951

Hans-Ulrich Demuth

10

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Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/22375951

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publication date

28 March 2012

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Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/22375951

Journal of Neurochemistry

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13 February 2018

http://europepmc.org/abstract/MED/22375951

121

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13 February 2018

http://europepmc.org/abstract/MED/22375951

5

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http://europepmc.org/abstract/MED/22375951

774-784

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Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/22375951

Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07707.X

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Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways

1 reference

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ANS binding reveals common features of cytotoxic amyloid species

1 reference

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A causative link between the structure of aberrant protein oligomers and their toxicity.

1 reference

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Spectrofluorimetric assessment of the surface hydrophobicity of proteins

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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

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Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta

1 reference

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N-terminal truncated pyroglutamyl beta amyloid peptide Abetapy3-42 shows a faster aggregation kinetics than the full-length Abeta1-42.

1 reference

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Chromosome 13 dementia syndromes as models of neurodegeneration

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High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain

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The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta.

1 reference

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AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

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Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease.

1 reference

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21 January 2018

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

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21 January 2018

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

1 reference

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21 January 2018

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

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21 January 2018

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

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21 January 2018

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

1 reference

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21 January 2018

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07707.X

21 January 2018

Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques

1 reference

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21 January 2018

Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07707.X

21 January 2018

Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07707.X

21 January 2018

beta-amyloid is different in normal aging and in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07707.X

21 January 2018

The Na+/H+ exchanger modulates long-term potentiation in rat hippocampal slices

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07707.X

21 January 2018

Presenilin-1 mutations in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07707.X

21 January 2018

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07707.X

21 January 2018

Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07707.X

21 January 2018

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07707.X

21 January 2018

Generation of amyloid beta peptide with pyroglutamate at position 3 in primary cortical neurons

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07707.X

21 January 2018

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07707.X

21 January 2018

Deciphering the molecular basis of memory failure in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07707.X

21 January 2018

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07707.X

21 January 2018

Electrophoretic Separation of βA4 Peptides (1–40) and (1–42)

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07707.X

21 January 2018

Identifiers

10.1111/J.1471-4159.2012.07707.X

1 reference

Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/22375951

1 reference

Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/22375951

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