Ku80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs. (Q48511015)

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29 January 2020

title

Ku80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs (English)

1 reference

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29 January 2020

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2

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29 January 2020

author name string

V B Holcomb

1

1 reference

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29 January 2020

T Marple

3

1 reference

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29 January 2020

R W Kornegay

4

1 reference

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29 January 2020

P Hasty

5

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29 January 2020

language of work or name

English

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publication date

5 June 2006

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29 January 2020

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29 January 2020

volume

25

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29 January 2020

issue

54

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29 January 2020

page(s)

7159-7165

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209704

29 January 2020

exact match

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cites work

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Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

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The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system

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A role for DNA-PK in retroviral DNA integration

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Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification

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DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

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Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine

21 January 2018

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

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Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

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DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

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The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice.

21 January 2018

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Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

21 January 2018

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Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

21 January 2018

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Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice

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V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

21 January 2018

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DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

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CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas

21 January 2018

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No requirement for V(D)J recombination in p53-deficient thymic lymphoma

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Interferon-gamma induced medulloblastoma in the developing cerebellum.

21 January 2018

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Medulloblastoma: developmental mechanisms out of control

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Take care of your chromosomes lest cancer take care of you.

21 January 2018

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RAG-1-deficient mice have no mature B and T lymphocytes

21 January 2018

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21 January 2018

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Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

21 January 2018

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Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development

21 January 2018

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21 January 2018

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Both V(D)J coding ends but neither signal end can recombine at the bcl-2 major breakpoint region, and the rejoining is ligase IV dependent

21 January 2018

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Double-strand break formation by the RAG complex at the bcl-2 major breakpoint region and at other non-B DNA structures in vitro

21 January 2018

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A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex

21 January 2018

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21 January 2018

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Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

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Deletion of Ku86 causes early onset of senescence in mice

21 January 2018

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Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

21 January 2018

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21 January 2018

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