Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates (Q38354165)

2 September 2017

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates (English)

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severe combined immunodeficiency

2 September 2017

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3

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2 September 2017

C Zhu

1

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2 September 2017

M A Bogue

series ordinal

2

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2 September 2017

P Hasty

series ordinal

4

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2 September 2017

D B Roth

series ordinal

5

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2 September 2017

language of work or name

English

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publication date

1 August 1996

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2 September 2017

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2 September 2017

86

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2 September 2017

379-389

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2 September 2017

3

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Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter.

2 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

The interwoven architecture of the Mu transposase couples DNA synapsis to catalysis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

DNA-promoted assembly of the active tetramer of the Mu transposase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Mechanism of V(D)J recombination

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

A severe combined immunodeficiency mutation in the mouse

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

T-lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor delta gene recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

A DNA-activated protein kinase from HeLa cell nuclei

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Initiation of V(D)J recombination in vitro obeying the 12/23 rule

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Wild-type V(D)J recombination in scid pre-B cells

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Strand breaks without DNA rearrangement in V (D)J recombination

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

A constitutive heat shock element-binding factor is immunologically identical to the Ku autoantigen

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Disassembly of the Mu transposase tetramer by the ClpX chaperone

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

P nucleotide insertions and the resolution of hairpin DNA structures in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Novel strand exchanges in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

A new component of bacteriophage Mu replicative transposition machinery: the Escherichia coli ClpX protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

A simple assay for puromycin N-acetyltransferase: selectable marker and reporter

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

RAG-1-deficient mice have no mature B and T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Production and characterization of recombinant human Ku antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Analysis of the mechanism of interaction of simian Ku protein with DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

High frequency of normal DJH joints in B cell progenitors in severe combined immunodeficiency mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Differential effects of polyadenylation regions on gene expression in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Genomic DNA microextraction: A method to screen numerous samples

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Formation and resolution of double-strand break intermediates in V(D)J rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

A DNA end-binding factor involved in double-strand break repair and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Characterization of broken DNA molecules associated with V(D)J recombination

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Repair and recombination. How to make ends meet

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Mu transpositional recombination: donor DNA cleavage and strand transfer in trans by the Mu transposase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

The phage Mu transpososome core: DNA requirements for assembly and function.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Defective V-to-J recombination of T cell receptor gamma chain genes in scid mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

scid cells efficiently integrate hairpin and linear DNA substrates

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Transpososomes: Stable protein-DNA complexes involved in the in vitro transposition of bacteriophage Mu DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Impairment of V(D)J recombination in double-strand break repair mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Initiation of V(D)J recombination in a cell-free system.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

What to do at an end: DNA double-strand-break repair

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

A molecular chaperone, ClpA, functions like DnaK and DnaJ.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

Characterization of coding ends in thymocytes of scid mice: implications for the mechanism of V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980111-7

7 January 2021

10.1016/S0092-8674(00)80111-7

Identifiers

DOI

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2 September 2017

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