Oil for the cancer engine: The cross-talk between oncogenic signaling and polyamine metabolism. (Q48154027)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29376126%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

2 references

26 August 2020

8 February 2021

Oil for the cancer engine: The cross-talk between oncogenic signaling and polyamine metabolism (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29376126%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

7 November 2019

1 reference

26 August 2020

1 reference

8 February 2021

Amaia Arruabarrena-Aristorena

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29376126%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

Amaia Zabala-Letona

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29376126%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

Arkaitz Carracedo

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29376126%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

author name string

Amaia Zabala-Letona

2

1 reference

http://europepmc.org/abstract/PMC/5783676

9 February 2018

Arkaitz Carracedo

3

1 reference

http://europepmc.org/abstract/PMC/5783676

9 February 2018

publication date

24 January 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29376126%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 January 2018

2 references

26 August 2020

8 February 2021

4 references

7 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29376126%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

26 August 2020

8 February 2021

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29376126%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

page(s)

eaar2606

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29376126%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29376126%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial 4.0 International

13 March 2020

copyright license

3 references

7 November 2019

26 August 2020

Molecular definitions of autophagy and related processes.

8 February 2021

cites work

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Spermidine/spermine N1-acetyltransferase regulates cell growth and metastasis via AKT/β-catenin signaling pathways in hepatocellular and colorectal carcinoma cells

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Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling

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Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses

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Targeting ODC1 inhibits tumor growth through reduction of lipid metabolism in human hepatocellular carcinoma

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Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

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P/CAF-mediated spermidine acetylation regulates histone acetyltransferase activity.

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The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma

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Polyamine Antagonist Therapies Inhibit Neuroblastoma Initiation and Progression

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Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

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Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice

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Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth

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Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age.

22 May 2018

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Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ).

22 May 2018

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The role for autophagy in cancer

22 May 2018

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Spermidine induces autophagy by inhibiting the acetyltransferase EP300.

22 May 2018

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The polyamine catabolic enzyme SAT1 modulates tumorigenesis and radiation response in GBM

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A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer

22 May 2018

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A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation

22 May 2018

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Unravelling mechanisms of p53-mediated tumour suppression

22 May 2018

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Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan

22 May 2018

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Regulation of autophagy by cytosolic acetyl-coenzyme A.

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Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans.

22 May 2018

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Blocking eIF5A modification in cervical cancer cells alters the expression of cancer-related genes and suppresses cell proliferation

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Polyamines and their metabolites as diagnostic markers of human diseases.

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Modulation of polyamine metabolic flux in adipose tissue alters the accumulation of body fat by affecting glucose homeostasis.

22 May 2018

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Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

22 May 2018

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Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma.

22 May 2018

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A tumour suppressor network relying on the polyamine-hypusine axis

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Spermine, a molecular switch regulating EGFR, integrin β3, Src, and FAK scaffolding

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Ornithine decarboxylase mRNA is stabilized in an mTORC1-dependent manner in Ras-transformed cells.

22 May 2018

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Aerobic glycolysis: meeting the metabolic requirements of cell proliferation

22 May 2018

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

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22 May 2018

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Hallmarks of Cancer: The Next Generation

22 May 2018

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Initial testing (stage 1) of the polyamine analog PG11047 by the pediatric preclinical testing program.

22 May 2018

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Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

22 May 2018

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The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation

22 May 2018

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22 May 2018

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Induction of autophagy by spermidine promotes longevity

22 May 2018

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22 May 2018

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The polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer

22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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Polyamine Depletion Increases Cytoplasmic Levels of RNA-binding Protein HuR Leading to Stabilization of Nucleophosmin and p53 mRNAs

22 May 2018

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Polyamine analogues down-regulate estrogen receptor alpha expression in human breast cancer cells.

22 May 2018

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Elevated levels of ornithine decarboxylase cooperate with Raf/ERK activation to convert normal keratinocytes into invasive malignant cells

22 May 2018

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Polyamine depletion induces nucleophosmin modulating stability and transcriptional activity of p53 in intestinal epithelial cells

22 May 2018

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Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizyme

22 May 2018

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A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis

22 May 2018

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22 May 2018

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A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer.

22 May 2018

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Transcriptional and translational control of ornithine decarboxylase during Ras transformation.

22 May 2018

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A novel polyamine analog inhibits growth and induces apoptosis in human breast cancer cells.

22 May 2018

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Genomic targets of the human c-Myc protein

22 May 2018

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22 May 2018

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Polyamines regulate beta-catenin tyrosine phosphorylation via Ca(2+) during intestinal epithelial cell migration

22 May 2018

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Phase I study of N(1),N(11)-diethylnorspermine in patients with non-small cell lung cancer.

22 May 2018

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22 May 2018

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Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal epithelial cell proliferation

22 May 2018

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A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours.

22 May 2018

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Phase I and pharmacological study of weekly administration of the polyamine synthesis inhibitor SAM 486A (CGP 48 664) in patients with solid tumors. European Organization for Research and Treatment of Cancer Early Clinical Studies Group

22 May 2018

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High levels of intracellular polyamines promote histone acetyltransferase activity resulting in chromatin hyperacetylation

22 May 2018

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Probing the mechanism of transport and compartmentalisation of polyamines in mammalian cells.

22 May 2018

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Inhibition of polyamine synthesis induces p53 gene expression but not apoptosis

22 May 2018

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Polyamine depletion arrests cell cycle and induces inhibitors p21(Waf1/Cip1), p27(Kip1), and p53 in IEC-6 cells

22 May 2018

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S-Adenosylmethionine and methylation

22 May 2018

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Codeletion of the genes for p16INK4, methylthioadenosine phosphorylase, interferon-alpha1, interferon-beta1, and other 9p21 markers in human malignant cell lines

22 May 2018

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Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues

22 May 2018

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4-Amidinoindan-1-one 2'-amidinohydrazone: a new potent and selective inhibitor of S-Adenosylmethionine decarboxylase

22 May 2018

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Synthetic polyamines stimulate in vitro transcription by T7 RNA polymerase

22 May 2018

1 reference

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Dioxopiperazine derivative potentiates antitumor effect of methylglyoxal bis(cyclopentylamidinohydrazone) on human and mouse leukemia cells

22 May 2018

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Identification of hypusine, an unusual amino acid, in a protein from human lymphocytes and of spermidine as its biosynthetic precursor

22 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Identification of the hypusine-containing protein hy+ as translation initiation factor eIF-4D.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Hypusine, a new amino acid occurring in bovine brain. Isolation and structural determination

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Polyamines and HeLa-cell DNA replication

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Phase I trial of alpha-difluoromethyl ornithine (DFMO) and methylglyoxal bis (guanylhydrazone) (MGBG) in patients with advanced prostatic cancer

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Phase II trials of alpha-difluoromethylornithine, an inhibitor of polyamine synthesis, in advanced small cell lung cancer and colon cancer.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

The upstream open reading frame of the mRNA encoding S-adenosylmethionine decarboxylase is a polyamine-responsive translational control element.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Estimation of polyamine binding to macromolecules and ATP in bovine lymphocytes and rat liver

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Role of polyamines at the G1/S boundary and G2/M phase of the cell cycle.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Polyamine production is downstream and upstream of oncogenic PI3K signalling and contributes to tumour cell growth

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Enhanced osteoblastogenesis of adipose-derived stem cells on spermine delivery via β-catenin activation.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Genetically altered expression of spermidine/spermine N1-acetyltransferase affects fat metabolism in mice via acetyl-CoA.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Molecular modeling of the human eukaryotic translation initiation factor 5A (eIF5A) based on spectroscopic and computational analyses.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Regulation of heart insulin receptor tyrosine kinase activity by magnesium and spermine

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Multi-centre Phase II trial of the polyamine synthesis inhibitor SAM486A (CGP48664) in patients with metastatic melanoma

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Activated polyamine catabolism depletes acetyl-CoA pools and suppresses prostate tumor growth in TRAMP mice

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Phase I trial of the polyamine analog N1,N14-diethylhomospermine (DEHSPM) in patients with advanced solid tumors

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

A phase I and pharmacokinetic study of SAM486A, a novel polyamine biosynthesis inhibitor, administered on a daily-times-five every-three-week schedule in patients with Advanced solid malignancies.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Essential role of S-adenosylmethionine decarboxylase in mouse embryonic development

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Phase 1 study of N1-N11-diethylnorspermine (DENSPM) administered TID for 6 days in patients with advanced malignancies

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

Spermine-Enhanced Protein Phosphorylation in Human Placenta

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783676

The relationship between polyamine accumulation and DNA replication in synchronized Chinese hamster ovary cells after heat shock

14 August 2018

1 reference

12 December 2020

Inhibition of enzymes of polyamine back-conversion by pentamidine and berenil

1 reference

12 December 2020

Comparative studies on the polyamine metabolism and DFMO treatment of MCF-7 and MDA-MB-231 breast cancer cell lines and xenografts

1 reference

12 December 2020

[Inhibition by polyamine biosynthesis inhibitor DFMO of the growth of transplanted human colon cancer in nude mice]

1 reference

12 December 2020

Polyamines differentially modulate the transcription of growth-associated genes in human colon carcinoma cells

1 reference

12 December 2020

Treatment of hamster pancreatic cancer with alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis

1 reference

12 December 2020

N-2,3-Butadienyl-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase

1 reference

12 December 2020

Biosynthesis of Putrescine: Characterization of Ornithine Decarboxylase from Regenerating Rat Liver

1 reference

12 December 2020

Antigrowth effect of some inhibitors of polyamine synthesis on transplantable prostate cancer

1 reference

12 December 2020

CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity

1 reference

12 December 2020

Formation of a complex containing ATP, Mg2+, and spermine. Structural evidence and biological significance

1 reference

12 December 2020

Polyamine analogue induction of the p53-p21WAF1/CIP1-Rb pathway and G1 arrest in human melanoma cells

1 reference

12 December 2020

Growth inhibition of human osteosarcoma HuO9 cells by methylglyoxal bis(cyclopentylamidinohydrazone) in vitro and in vivo

1 reference

12 December 2020

Prevention of metastasis by a polyamine synthesis inhibitor in an animal bone metastasis model

1 reference

12 December 2020

Novel lysine-spermine conjugate inhibits polyamine transport and inhibits cell growth when given with DFMO

1 reference

12 December 2020

Polyamine biosynthesis in relation to K‐ras and p‐53 mutations in colorectal carcinoma

1 reference

12 December 2020

Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL-positive leukemias identified by a proteomics approach

1 reference

12 December 2020

Arginine decarboxylase and agmatinase: an alternative pathway for de novo biosynthesis of polyamines for development of mammalian conceptuses

1 reference

12 December 2020

Identifiers

DOI

10.1126/SCIADV.AAR2606

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29376126%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29376126%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference