Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma. (Q41107342)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23181218%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

title

Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma (English)

1 reference

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18 February 2020

7

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18 February 2020

author name string

Laura D Gamble

1

1 reference

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18 February 2020

Michael D Hogarty

2

1 reference

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18 February 2020

Xueyuan Liu

3

1 reference

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18 February 2020

David S Ziegler

4

1 reference

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18 February 2020

Glenn Marshall

5

1 reference

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18 February 2020

Murray D Norris

6

1 reference

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18 February 2020

publication date

16 November 2012

1 reference

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18 February 2020

published in

Frontiers in Oncology

1 reference

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18 February 2020

volume

2

1 reference

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18 February 2020

page(s)

162

1 reference

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COX-2-independent induction of apoptosis by celecoxib and polyamine naphthalimide conjugate mediated by polyamine depression in colorectal cancer cell lines

18 February 2020

cites work

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Apoptosis induced by the potential chemotherapeutic drug N1, N11-Diethylnorspermine in a neuroblastoma cell line

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Synergistic anticancer effects of combined gamma-tocotrienol and celecoxib treatment are associated with suppression in Akt and NFkappaB signaling

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The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines

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The polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer

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Mammalian polyamine metabolism and function

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Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma

26 September 2017

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Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor

26 September 2017

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Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma

26 September 2017

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F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system

26 September 2017

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Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma

26 September 2017

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ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma

26 September 2017

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Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial

26 September 2017

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Identification and characterization of a diamine exporter in colon epithelial cells

26 September 2017

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Different cell cycle kinetic effects of N1,N11-diethylnorspermine-induced polyamine depletion in four human breast cancer cell lines

26 September 2017

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Synthesis, cytotoxicity and apoptosis of naphthalimide polyamine conjugates as antitumor agents

26 September 2017

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Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function

26 September 2017

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In vitro and in vivo effects of the conformationally restricted polyamine analogue CGC-11047 on small cell and non-small cell lung cancer cells

26 September 2017

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The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trial

26 September 2017

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Polyamine acetylation modulates polyamine metabolic flux, a prelude to broader metabolic consequences

26 September 2017

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Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase

26 September 2017

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26 September 2017

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26 September 2017

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26 September 2017

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Overexpression of antizyme-inhibitor in NIH3T3 fibroblasts provides growth advantage through neutralization of antizyme functions

26 September 2017

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26 September 2017

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Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells

26 September 2017

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Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizyme

26 September 2017

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Polyamines and cancer: old molecules, new understanding

26 September 2017

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A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer.

26 September 2017

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Cyclooxygenase-independent Induction of Apoptosis by Sulindac Sulfone Is Mediated by Polyamines in Colon Cancer

26 September 2017

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Polyamine-dependent gene expression

26 September 2017

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Polyamine metabolism and cancer.

26 September 2017

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A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

26 September 2017

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Properties of purified recombinant human polyamine oxidase, PAOh1/SMO

26 September 2017

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26 September 2017

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The role of polyamine catabolism in anti-tumour drug response

26 September 2017

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26 September 2017

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JunD stabilization results in inhibition of normal intestinal epithelial cell growth through P21 after polyamine depletion

26 September 2017

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26 September 2017

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Phase I study of N(1),N(11)-diethylnorspermine in patients with non-small cell lung cancer.

26 September 2017

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Polyamines and colon cancer.

26 September 2017

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Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure

26 September 2017

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Polyamine depletion arrests growth of IEC-6 and Caco-2 cells by different mechanisms

26 September 2017

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Antitumor activity of the polyamine analog N(1), N(11)-diethylnorspermine against human prostate carcinoma cells

26 September 2017

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K6/ODC transgenic mice as a sensitive model for carcinogen identification

26 September 2017

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Polyamines: mysterious modulators of cellular functions

26 September 2017

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alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model

26 September 2017

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Development of difluoromethylornithine (DFMO) as a chemoprevention agent.

26 September 2017

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Overexpression of ornithine decarboxylase in prostate cancer and prostatic fluid in humans

26 September 2017

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N1,N12-bis(ethyl)spermine effect on growth of cis-diamminedichloroplatinum(II)-sensitive and -resistant human ovarian-carcinoma cell lines

26 September 2017

1 reference

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Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells

26 September 2017

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Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor

26 September 2017

1 reference

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Targeted expression of MYCN causes neuroblastoma in transgenic mice

26 September 2017

1 reference

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Modulation of channel function by polyamines

26 September 2017

1 reference

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Structure and critical residues at the active site of spermidine/spermine-N1-acetyltransferase

26 September 2017

1 reference

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Cloning of antizyme inhibitor, a highly homologous protein to ornithine decarboxylase

26 September 2017

1 reference

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Polyamine oxidase, properties and functions

26 September 2017

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Spermidine/spermine N1-acetyltransferase--the turning point in polyamine metabolism

26 September 2017

1 reference

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Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues

26 September 2017

1 reference

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Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells

26 September 2017

1 reference

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The ornithine decarboxylase gene is a transcriptional target of c-Myc

26 September 2017

1 reference

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Antizyme protects against abnormal accumulation and toxicity of polyamines in ornithine decarboxylase-overproducing cells

26 September 2017

1 reference

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Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme

26 September 2017

1 reference

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Polyamines alter sequence-specific DNA-protein interactions

26 September 2017

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Polyamines in mammalian tumors. Part I.

26 September 2017

1 reference

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Identification of the hypusine-containing protein hy+ as translation initiation factor eIF-4D.

26 September 2017

1 reference

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Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy

26 September 2017

1 reference

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Effects of treatment with DNA-directed cancer chemotherapeutic agents after polyamine depletion

26 September 2017

1 reference

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Regulated degradation of ornithine decarboxylase requires interaction with the polyamine-inducible protein antizyme

26 September 2017

1 reference

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Comparison of androgen regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase gene expression in rodent kidney and accessory sex organs

26 September 2017

1 reference

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Polyamines in rapid growth and cancer

26 September 2017

1 reference

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Polyamine transport in mammalian cells. An update

26 September 2017

1 reference

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Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells.

27 September 2017

1 reference

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Exposure to ornithine results in excessive accumulation of putrescine and apoptotic cell death in ornithine decarboxylase overproducing mouse myeloma cells.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

Chemoprevention of B-cell lymphomas by inhibition of the Myc target spermidine synthase

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

A putrescine-anthracene conjugate: a paradigm for selective drug delivery

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

Activated K-RAS increases polyamine uptake in human colon cancer cells through modulation of caveolar endocytosis

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culture cells

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

Treatment of gambiense sleeping sickness in the Sudan with oral DFMO (DL-alpha-difluoromethylornithine), an inhibitor of ornithine decarboxylase; first field trial

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

Ornithine decarboxylase activity is critical for cell transformation

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

Induction of the polyamine-biosynthetic enzymes in mouse epidermis and their specificity for tumor promotion

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

Enhancement of the spermidine uptake system and lethal effects of spermidine overaccumulation in ornithine decarboxylase-overproducing L1210 cells under hyposmotic stress.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

Polyamines and prostatic carcinoma: clinical and therapeutic implications.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

MYCN amplification remains prognostically strong 20 years after its “clinical debut”

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

Eflornithine for African sleeping sickness

2 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499881

Analysis of candidate gene co-amplification with MYCN in neuroblastoma

2 December 2018

1 reference

12 December 2020

Conformationally restricted analogues of 1N,12N-bisethylspermine: synthesis and growth inhibitory effects on human tumor cell lines

1 reference

12 December 2020

The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine

1 reference

12 December 2020

Polyamine profiles in tumor, normal tissue of the homologous breast, blood, and urine of breast cancer sufferers

1 reference

12 December 2020

Novel lysine-spermine conjugate inhibits polyamine transport and inhibits cell growth when given with DFMO

1 reference

12 December 2020

1 reference

12 December 2020

Polyamine deprivation enhances antitumoral efficacy of chemotherapy

1 reference

12 December 2020

New S-adenosylmethionine decarboxylase inhibitors with potent antitumor activity

1 reference

12 December 2020

Antimetastatic activity of DL-alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis, in mice

1 reference

12 December 2020

Effects of alpha-difluoromethylornithine alone and combined with adriamycin or vindesine on L1210 leukemia in mice, EMT6 solid tumors in mice, and solid tumors induced by injection of hepatoma tissue culture cells in rats

1 reference

12 December 2020

Accumulation of decarboxylated S-adenosyl-L-methionine in mammalian cells as a consequence of the inhibition of putrescine biosynthesis

1 reference

12 December 2020

CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity

1 reference

12 December 2020

Growth inhibition of hormone-responsive and -resistant human breast cancer cells in culture by N1, N12-bis(ethyl)spermine

1 reference

12 December 2020

Neuroblastomas have distinct genomic DNA profiles that predict clinical phenotype and regional gene expression

1 reference

12 December 2020

Chemoprevention of human actinic keratoses by topical 2-(difluoromethyl)-dl-ornithine

1 reference

12 December 2020

Identifiers

DOI

10.3389/FONC.2012.00162

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23181218%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23181218%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23181218%20AND%20SRC:MED&resulttype=core&format=json