MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells (Q37203229)

18 August 2017

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells (English)

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18 August 2017

5

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31 May 2020

Francisca Vazquez

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31 May 2020

Clary B Clish

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31 May 2020

21

Levi A Garraway

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31 May 2020

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Todd R Golub

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31 May 2020

20

William C Hahn

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31 May 2020

16

David E Root

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31 May 2020

15

Jesse S Boehm

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31 May 2020

14

Glenn S Cowley

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31 May 2020

8

Barbara A Weir

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31 May 2020

author name string

Gregory V Kryukov

1

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31 May 2020

Frederick H Wilson

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31 May 2020

Jason R Ruth

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31 May 2020

Joshiawa Paulk

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31 May 2020

Sara E Marlow

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31 May 2020

Mark E Fitzgerald

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31 May 2020

Minoru Tanaka

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31 May 2020

Craig M Bielski

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31 May 2020

Justin M Scott

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31 May 2020

Courtney Dennis

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31 May 2020

James E Bradner

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31 May 2020

language of work or name

English

0 references

publication date

11 February 2016

1 reference

18 August 2017

5

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based on heuristic

inferred from page(s)

published in

Science

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31 May 2020

volume

351

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31 May 2020

page(s)

1214-1218

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31 May 2020

issue

6278

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Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

31 May 2020

cites work

1 reference

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Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis

6 September 2017

1 reference

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Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

6 September 2017

1 reference

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MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

6 September 2017

1 reference

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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

6 September 2017

1 reference

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PRMT5 is essential for the eIF4E-mediated 5'-cap dependent translation

6 September 2017

1 reference

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6-thioguanine: a drug with unrealized potential for cancer therapy

6 September 2017

1 reference

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Assay development for histone methyltransferases

6 September 2017

1 reference

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Protein arginine methyltransferases and cancer

6 September 2017

1 reference

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The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

6 September 2017

1 reference

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

6 September 2017

1 reference

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A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens

6 September 2017

1 reference

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Versatility of PRMT5-induced methylation in growth control and development.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997612

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

6 September 2017

1 reference

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Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategies

6 September 2017

1 reference

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PRMT5 is required for cell-cycle progression and p53 tumor suppressor function

6 September 2017

1 reference

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PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.

6 September 2017

1 reference

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Concordant loss of MTAP and p16/CDKN2A expression in gastroesophageal carcinogenesis: evidence of homozygous deletion in esophageal noninvasive precursor lesions and therapeutic implications

6 September 2017

1 reference

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Arginine methylation an emerging regulator of protein function

6 September 2017

1 reference

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Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy

6 September 2017

1 reference

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Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line

6 September 2017

1 reference

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A novel WD repeat protein component of the methylosome binds Sm proteins

6 September 2017

1 reference

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The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins

6 September 2017

1 reference

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The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity

6 September 2017

1 reference

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Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers

6 September 2017

1 reference

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Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers

6 September 2017

1 reference

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Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas.

14 September 2017

1 reference

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Trends in the biochemical pharmacology of 5'-deoxy-5'-methylthioadenosine

14 September 2017

1 reference

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Gene deletion chemoselectivity: codeletion of the genes for p16(INK4), methylthioadenosine phosphorylase, and the alpha- and beta-interferons in human pancreatic cell carcinoma lines and its implications for chemotherapy

14 September 2017

1 reference

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RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.

28 September 2017

1 reference

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Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

26 June 2018

1 reference

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A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancer

26 June 2018

1 reference

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PRMT5 (Janus Kinase-binding Protein 1) Catalyzes the Formation of Symmetric Dimethylarginine Residues in Proteins

3 September 2018

1 reference

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3 September 2018

Identifiers

DOI

10.1126/SCIENCE.AAD5214

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912360%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912360%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference