The Molecular Mechanism of Glucagon-Like Peptide-1 Therapy in Alzheimer's Disease, Based on a Mechanistic Target of Rapamycin Pathway. (Q48060988)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28540646%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

title

The Molecular Mechanism of Glucagon-Like Peptide-1 Therapy in Alzheimer's Disease, Based on a Mechanistic Target of Rapamycin Pathway (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28540646%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28540646%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

author name string

Lin Li

series ordinal

1

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http://europepmc.org/abstract/MED/28540646

8 February 2018

publication date

1 July 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28540646%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28540646%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

volume

31

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28540646%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

issue

7

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28540646%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

page(s)

535-549

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28540646%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s40263-017-0431-2

21 March 2020

exact match

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cites work

Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease.

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Vascular dysfunction associated with type 2 diabetes and Alzheimer's disease: a potential etiological linkage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

mTOR is a key modulator of ageing and age-related disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Targeting mammalian target of rapamycin (mTOR) for health and diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Target of rapamcyin (TOR)-based therapeutics for cardiomyopathy: insights from zebrafish genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Targeting mTOR: something old, something new.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Effects of rapamycin and TOR on aging and memory: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

mTOR signaling in growth control and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Mammalian target of rapamycin signaling in diabetic cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Regulation of translation initiation in eukaryotes: mechanisms and biological targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Amino acid regulation of TOR complex 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

The TOR pathway comes of age

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

The Free Radical Theory of Aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Subfield history: caloric restriction, slowing aging, and extending life

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Glucose levels and risk of dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Potential role of glucagon-like peptide-1 (GLP-1) in neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Mechanisms of nitrosamine-mediated neurodegeneration: potential relevance to sporadic Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Metabolic changes in rat brain following intracerebroventricular injections of streptozotocin: a model of sporadic Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Leptin treatment ameliorates anxiety in ob/ob obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Effects of leptin on memory processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Dietary fat up-regulates the apolipoprotein E mRNA level in the Zucker lean rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid β.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Behavioral and biochemical effects of an ICV injection of streptozotocin in old Lewis rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Brain gene expression of a sporadic (icv-STZ Mouse) and a familial mouse model (3xTg-AD mouse) of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Insulin increases CSF Abeta42 levels in normal older adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

The role of insulin, insulin growth factor, and insulin-degrading enzyme in brain aging and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Does insulin dysfunction play a role in Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Damaged neuronal energy metabolism and behavior are improved by Ginkgo biloba extract (EGb 761).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Type 3 diabetes is sporadic Alzheimer׳s disease: mini-review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Regional cerebral glucose transport and utilization in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Intracerebroventricular administration of an insulin analogue recovers STZ-induced cognitive decline in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Insulin and insulin-like growth factor prevent brain atrophy and cognitive impairment in diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Glimepiride protects neurons against amyloid-β-induced synapse damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Endogenous insulin signaling protects cultured neurons from oxygen-glucose deprivation-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Pharmacophore modeling, homology modeling, and in silico screening reveal mammalian target of rapamycin inhibitory activities for sotalol, glyburide, metipranolol, sulfamethizole, glipizide, and pioglitazone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Insulin has multiple antiamyloidogenic effects on human neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

(Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Mechanisms of neurodegeration in type 2 diabetes and the neuroprotective potential of dipeptidyl peptidase 4 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Geniposide ameliorates learning memory deficits, reduces tau phosphorylation and decreases apoptosis via GSK3β pathway in streptozotocin-induced alzheimer rat model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

The functions of mTOR in ischemic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Nutrient-dependent regulation of autophagy through the target of rapamycin pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Rapamycin alleviates toxicity of different aggregate-prone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Driving neural regeneration through the mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

mTORC1 targets the translational repressor 4E-BP2, but not S6 kinase 1/2, to regulate neural stem cell self-renewal in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

RTP801/REDD1 regulates the timing of cortical neurogenesis and neuron migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Mammalian target of rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Cutting through the complexities of mTOR for the treatment of stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Tuberous sclerosis protein 2 (TSC2) modulates CCN4 cytoprotection during apoptotic amyloid toxicity in microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Wogonin increases β-amyloid clearance and inhibits tau phosphorylation via inhibition of mammalian target of rapamycin: potential drug to treat Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Increased phosphorylation of mTOR is involved in remote ischemic preconditioning of hippocampus in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Neural mechanisms of ageing and cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Systematic gene expression profile of hypothalamus in calorie-restricted mice implicates the involvement of mTOR signaling in neuroprotective activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Rapamycin protects against Aβ-induced synaptotoxicity by increasing presynaptic activity in hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

The immunosuppressant rapamycin exacerbates neurotoxicity of Abeta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Rapamycin promotes beta-amyloid production via ADAM-10 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

μ-Opioid receptor attenuates Aβ oligomers-induced neurotoxicity through mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Leptin inhibits amyloid β-protein fibrillogenesis by decreasing GM1 gangliosides on the neuronal cell surface through PI3K/Akt/mTOR pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Glucagon-like peptide 1 (GLP-1) can reverse AMP-activated protein kinase (AMPK) and S6 kinase (P70S6K) activities induced by fluctuations in glucose levels in hypothalamic areas involved in feeding behaviour.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Exendin-4 stimulates islet cell replication via the IGF1 receptor activation of mTORC1/S6K1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Corrigendum: Glucagon-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improving mitochondrial function and suppressing prolonged AMPK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

SAD-A and AMPK kinases: the "yin and yang" regulators of mTORC1 signaling in pancreatic β cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Central glucagon-like peptide 1 receptor-induced anorexia requires glucose metabolism-mediated suppression of AMPK and is impaired by central fructose

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Critical roles for the TSC-mTOR pathway in β-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

SAD-A kinase controls islet β-cell size and function as a mediator of mTORC1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

SAD-A potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like peptide 1 response in pancreatic β cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Exendin-4 alleviates high glucose-induced rat mesangial cell dysfunction through the AMPK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

DPP IV inhibitor suppresses STZ-induced islets injury dependent on activation of the IGFR/Akt/mTOR signaling pathways by GLP-1 in monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

The Rapamycin and FKBP12 Target (RAFT) Displays Phosphatidylinositol 4-Kinase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-017-0431-2

Dysfunctional pro-ceramide, ER stress, and insulin/IGF signaling networks with progression of Alzheimer's disease

21 January 2018

1 reference

12 December 2020

Antidiabetic drugs and their potential role in treating mild cognitive impairment and Alzheimer's disease

1 reference

12 December 2020

Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia

1 reference

12 December 2020

Hyperglycemia-induced tau cleavage in vitro and in vivo: a possible link between diabetes and Alzheimer's disease.

1 reference

12 December 2020

Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study

1 reference

12 December 2020

Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach

1 reference

12 December 2020

Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats.

1 reference

12 December 2020

New animal models of Alzheimer's disease that display insulin desensitization in the brain

1 reference

12 December 2020

Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor

1 reference

12 December 2020

Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin

1 reference

12 December 2020

Molecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisal

1 reference

12 December 2020

Neuroprotective effects of geniposide on Alzheimer's disease pathology

1 reference

12 December 2020

Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications.

1 reference

12 December 2020

Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease

1 reference

12 December 2020

Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease.

1 reference

12 December 2020

Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis.

1 reference

12 December 2020

10.1007/S40263-017-0431-2

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28540646%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference