The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo (Q46725222)

24 December 2017

title

The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo (English)

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24 December 2017

author name string

Emmy W Verschuren

1

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24 December 2017

Juha Klefstrom

2

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24 December 2017

Gerard I Evan

3

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24 December 2017

Nic Jones

4

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24 December 2017

publication date

1 September 2002

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24 December 2017

published in

Cancer Cell

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24 December 2017

volume

2

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24 December 2017

page(s)

229-241

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24 December 2017

issue

3

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24 December 2017

Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

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Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma

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Novel properties of the cyclin encoded by Human Herpesvirus 8 that facilitate exit from quiescence

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E1A signaling to p53 involves the p19(ARF) tumor suppressor

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Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex

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E2F-1 functions in mice to promote apoptosis and suppress proliferation

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p53 inhibition by the LANA protein of KSHV protects against cell death

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Apoptosis inhibitor as a suppressor of tumor progression: expression of Bcl-2 eliminates selective advantages for p53-deficient cells in the tumor

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"It takes two to tango": understanding how centrosome duplication is regulated throughout the cell cycle

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Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis

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c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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Expression of p53 and human herpesvirus-8 (HHV-8)-encoded latency-associated nuclear antigen with inhibition of apoptosis in HHV-8-associated malignancies

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Cyclin-dependent kinase control of centrosome duplication

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7 January 2021

Viral cyclin-cyclin-dependent kinase 6 complexes initiate nuclear DNA replication

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7 January 2021

Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

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7 January 2021

Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin.

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7 January 2021

Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

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7 January 2021

Modulation of p27(Kip1) levels by the cyclin encoded by Kaposi's sarcoma-associated herpesvirus

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7 January 2021

Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

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7 January 2021

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

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7 January 2021

p19ARF links the tumour suppressor p53 to Ras

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7 January 2021

E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways

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7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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7 January 2021

Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53

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p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption

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7 January 2021

p53 Signaling and cell cycle checkpoints

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7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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7 January 2021

Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins.

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Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

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7 January 2021

Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation

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7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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7 January 2021

Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma

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7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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7 January 2021

10.1016/S1535-6108(02)00123-X

Identifiers

DOI

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24 December 2017

PubMed ID

12242155

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24 December 2017