Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p. (Q46016417)

18 December 2017

title

Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p. (English)

1 reference

18 December 2017

author name string

Aaron Reinke

1

1 reference

18 December 2017

Jenny C-Y Chen

2

1 reference

18 December 2017

Sofia Aronova

3

1 reference

18 December 2017

Ted Powers

4

1 reference

18 December 2017

language of work or name

English

0 references

publication date

21 August 2006

1 reference

18 December 2017

Journal of Biological Chemistry

published in

1 reference

18 December 2017

volume

281

1 reference

18 December 2017

page(s)

31616-31626

1 reference

18 December 2017

issue

42

1 reference

18 December 2017

TOR signaling in growth and metabolism

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Molecular organization of target of rapamycin complex 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

TOR, a central controller of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Control of p70 s6 kinase by kinase activity of FRAP in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Raptor, a binding partner of target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Attenuation of mammalian target of rapamycin activity by increased cAMP in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Caffeine and human DNA metabolism: the magic and the mystery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Cell wall integrity signaling in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Regulatory mechanisms for modulation of signaling through the cell integrity Slt2-mediated pathway in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Regulation of the cell integrity pathway by rapamycin-sensitive TOR function in budding yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

In vitro mutagenesis and plasmid shuffling: from cloned gene to mutant yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Increased phosphoglucomutase activity suppresses the galactose growth defect associated with elevated levels of Ras signaling in S. cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

The TOR signaling cascade regulates gene expression in response to nutrients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Drosophila target of rapamycin kinase functions as a multimer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Targeting the gatekeeper residue in phosphoinositide 3-kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Receptor internalization in yeast requires the Tor2-Rho1 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Saccharomyces cerevisiaeTSC11/AVO3 participates in regulating cell integrity and functionally interacts with components of the Tor2 complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

The identification of a second cell cycle control on the HO promoter in yeast: cell cycle regulation of SW15 nuclear entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603107200

21 January 2018

Identifiers

DOI

10.1074/JBC.M603107200

1 reference

18 December 2017

PubMed ID

16923813

1 reference

18 December 2017