Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes (Q28238338)

1

0 references

Christopher D Armour

2

0 references

Sergey B Stepaniants

3

0 references

Guy Cavet

4

0 references

Maria K Wolf

5

0 references

J Scott Butler

6

0 references

Jerald C Hinshaw

7

0 references

Philippe Garnier

8

0 references

Glenn D Prestwich

9

0 references

Amy Leonardson

10

0 references

Philip Garrett-Engele

11

0 references

Christopher M Rush

12

0 references

Martin Bard

13

0 references

Greg Schimmack

14

0 references

John W Phillips

15

0 references

Christopher J Roberts

16

0 references

Daniel D Shoemaker

Molecular cloning, characterization, and functional expression of rat oxidosqualene cyclase cDNA

17

0 references

publication date

9 January 2004

0 references

language of work or name

0 references

0 references

116

0 references

issue

1

0 references

page(s)

121-37

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Degradation of ribosomal RNA precursors by the exosome

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Evolution of substrate specificities in the P-type ATPase superfamily.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Epoxidation of 2,3-oxidosqualene to 2,3;22,23-squalene dioxide by squalene epoxidase.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Asparagine-Linked Glycosylation in Saccharomyces cerevisiae: Genetic Analysis of an Early Step

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Rrp6p, the Yeast Homologue of the Human PM-Scl 100-kDa Autoantigen, Is Essential for Efficient 5.8 S rRNA 3′ End Formation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

The yin and yang of the exosome

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Molecular cloning, characterization, and overexpression of ERG7, the Saccharomyces cerevisiae gene encoding lanosterol synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Yph1p, an ORC-interacting protein: potential links between cell proliferation control, DNA replication, and ribosome biogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Mak21p of Saccharomyces cerevisiae, a homolog of human CAATT-binding protein, is essential for 60 S ribosomal subunit biogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Modulation of 5-fluorouracil metabolism by thymidine. In vivo and in vitro studies on RNA-directed effects in rat liver and hepatoma

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Ssf1p prevents premature processing of an early pre-60S ribosomal particle

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Human genetic diseases: a cross-talk between man and yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

A novel protein complex promoting formation of functional alpha - and gamma -tubulin

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Genomic profiling of drug sensitivities via induced haploinsufficiency.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

The impact of protein biochips and microarrays on the drug development process

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Functional discovery via a compendium of expression profiles

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

The gene encoding squalene epoxidase from Saccharomyces cerevisiae: cloning and characterization

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Drug treatment of lipid disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Initial sequencing and analysis of the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

5-Fluorouracil: mechanisms of action and clinical strategies

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

In vivo effects of fenpropimorph on the yeast Saccharomyces cerevisiae and determination of the molecular basis of the antifungal property

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Yeast oxidosqualene cyclase (Erg7p) is a major component of lipid particles

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Musing on the structural organization of the exosome complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Yeast sterol C8-C7 isomerase: identification and characterization of a high-affinity binding site for enzyme inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

The yeast plasma membrane proton pumping ATPase is a viable antifungal target. I. Effects of the cysteine-modifying reagent omeprazole

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Disruption of the GTP-cyclohydrolase I gene in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Isolation of the beta-tubulin gene from yeast and demonstration of its essential function in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Cloning, expression, and sequencing of squalene-hopene cyclase, a key enzyme in triterpenoid metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

A DNA microarray-based genetic screen for nonhomologous end-joining mutants in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Metabolism and mechanism of action of 5-fluorouracil

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Inhibition studies of sulfonamide-containing folate analogs in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Protein analysis on a proteomic scale

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Tricyclic antidepressants inhibit the Ca(2+)-dependent ATPase activity from plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Targeted selection of recombinant clones through gene dosage effects

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Relationships between sensitivity to hydroxyurea and 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone (MAIO) and ribonucleotide reductase RNR2 mRNA levels in strains of Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Does the ribosome translate cancer?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

The mechanism of action of cyclosporin A and FK506

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Biochemistry. Protein arrays step out of DNA's shadow

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Clomipramine and related structures as inhibitors of the skeletal sarcoplasmic reticulum Ca2+ pump

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Systematic screen for human disease genes in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Binding of cycloheximide to ribosomes from wild-type and mutant strains of Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

The yeast NOP4 gene product is an essential nucleolar protein required for pre-rRNA processing and accumulation of 60S ribosomal subunits.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Ribosome synthesis in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Oxidative stress is generated via the mitochondrial respiratory chain during plant cell apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

The metabolism of [14C]N-ethoxycarbonyl-3-morpholinosydnonimine (molsidomine) in man.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Characterization of a staurosporine- and temperature-sensitive mutant, stt1, of Saccharomyces cerevisiae: STT1 is allelic to PKC1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

Microarrays of cells expressing defined cDNAs

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901035-3

7 January 2021

10.1016/S0092-8674(03)01035-3

Identifiers

DOI

0 references

Fatcat ID

release_mh7wkkscz5e45lggwcb2qw4yne

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/mh7wkkscz5e45lggwcb2qw4yne

24 November 2022