K63-ubiquitylation of VHL by SOCS1 mediates DNA double-strand break repair (Q45363184)

13 December 2017

K63-ubiquitylation of VHL by SOCS1 mediates DNA double-strand break repair (English)

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13 December 2017

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J L Metcalf

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13 December 2017

P S Bradshaw

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13 December 2017

M Komosa

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13 December 2017

S N Greer

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13 December 2017

M Stephen Meyn

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13 December 2017

M Ohh

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13 December 2017

language of work or name

English

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publication date

4 March 2013

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13 December 2017

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13 December 2017

33

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13 December 2017

1055-1065

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13 December 2017

8

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https://scigraph.springernature.com/pub.10.1038/onc.2013.22

13 December 2017

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An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells.

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Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells

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Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

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Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

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Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S-G2 phase DNA double-strand break repair

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7 January 2021

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The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

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BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair

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Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

21 January 2018

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

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Regulation of endocytosis via the oxygen-sensing pathway

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Fibronectin is a hypoxia-independent target of the tumor suppressor VHL.

21 January 2018

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The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

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The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth

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VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.

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Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia.

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SOCS1 links cytokine signaling to p53 and senescence

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Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling

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Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density

21 January 2018

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Retracted: Ubiquitin/SUMO Modification Regulates VHL Protein Stability and Nucleocytoplasmic Localization

21 January 2018

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pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

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Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

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A proteomics approach to understanding protein ubiquitination

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Regulatory ubiquitylation in response to DNA double-strand breaks

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A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination

21 January 2018

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The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

21 January 2018

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Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells

21 January 2018

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Assaying double-strand break repair pathway choice in mammalian cells using a targeted endonuclease or the RAG recombinase

21 January 2018

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Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein

21 January 2018

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Role of nuclear and cytoplasmic localization in the tumour-suppressor activity of the von Hippel-Lindau protein.

21 January 2018

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The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation

21 January 2018

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E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

21 January 2018

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Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

21 January 2018

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A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

21 January 2018

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HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

21 January 2018

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Hypoxia-inducible factor-1alpha regulates the expression of nucleotide excision repair proteins in keratinocytes

21 January 2018

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Suppression of hypoxia-inducible factor 2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells

21 January 2018

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pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.22

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

21 January 2018

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Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

21 January 2018

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VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail

21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/ONC.2013.22

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Dimensions Publication ID

13 December 2017

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