An activated mTOR mutant supports growth factor-independent, nutrient-dependent cell survival (Q44888568)

7 December 2017

An activated mTOR mutant supports growth factor-independent, nutrient-dependent cell survival (English)

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7 December 2017

Aimee L Edinger

1

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PubMed ID

15133498

7 December 2017

Craig B Thompson

series ordinal

2

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PubMed ID

15133498

7 December 2017

language of work or name

English

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publication date

1 July 2004

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7 December 2017

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7 December 2017

23

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7 December 2017

5654-5663

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7 December 2017

33

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207738

7 December 2017

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cites work

The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

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FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

21 January 2018

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Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

21 January 2018

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Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression

21 January 2018

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Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo

21 January 2018

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

21 January 2018

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Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology

21 January 2018

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

21 January 2018

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The target of rapamycin (TOR) proteins

21 January 2018

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Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

21 January 2018

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The mRNA 5' cap-binding protein eIF4E and control of cell growth

21 January 2018

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Identification of TOR signaling complexes: more TORC for the cell growth engine

21 January 2018

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7 January 2021

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

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7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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7 January 2021

BAX and BAK mediate p53-independent suppression of tumorigenesis

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7 January 2021

Surface antigen CD98(4F2): not a single membrane protein, but a family of proteins with multiple functions

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7 January 2021

Pten is essential for embryonic development and tumour suppression

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7 January 2021

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

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7 January 2021

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

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7 January 2021

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

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7 January 2021

Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium.

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7 January 2021

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

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7 January 2021

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

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7 January 2021

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

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7 January 2021

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

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7 January 2021

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

1 reference

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7 January 2021

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

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7 January 2021

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

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7 January 2021

TSC2 mediates cellular energy response to control cell growth and survival

1 reference

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7 January 2021

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

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7 January 2021

Raf/MAPK and rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells

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7 January 2021

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

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7 January 2021

Correlation of growth capacity of human tumor cells in hard agarose with their in vivo proliferative capacity at specific metastatic sites

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7 January 2021

United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling

1 reference

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7 January 2021

TSC1–TSC2: a complex tale of PKB-mediated S6K regulation

1 reference

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7 January 2021

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207738

7 January 2021

Conformation of the Bax C-terminus regulates subcellular location and cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207738

7 January 2021

Molecular biology of mammalian plasma membrane amino acid transporters

1 reference

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7 January 2021

The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207738

7 January 2021

Akt regulates growth by directly phosphorylating Tsc2

1 reference

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7 January 2021

Rheb promotes cell growth as a component of the insulin/TOR signalling network

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207738

7 January 2021

TOR, a central controller of cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207738

7 January 2021

Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207738

7 January 2021

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207738

7 January 2021

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207738

7 January 2021

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207738

7 January 2021

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207738

7 January 2021

Growth factors can influence cell growth and survival through effects on glucose metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207738

7 January 2021

PI 3-kinase, mTOR, protein synthesis and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207738

7 January 2021

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207738

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207738

1 reference

7 December 2017

1 reference

PubMed ID

15133498