IGF-I elicits growth of human intestinal smooth muscle cells by activation of PI3K, PDK-1, and p70S6 kinase (Q44223760)

1 December 2017

IGF-I elicits growth of human intestinal smooth muscle cells by activation of PI3K, PDK-1, and p70S6 kinase (English)

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1 December 2017

John F Kuemmerle

1

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PubMed ID

12444011

1 December 2017

language of work or name

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20 November 2002

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American Journal of Physiology - Gastrointestinal and Liver Physiology

1 December 2017

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1 December 2017

284

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1 December 2017

3

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1 December 2017

G411-22

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1 December 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Role of translocation in the activation and function of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

The integrin-linked kinase (ILK) suppresses anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Disruption of 3-phosphoinositide-dependent kinase 1 (PDK1) signaling by the anti-tumorigenic and anti-proliferative agent n-alpha-tosyl-l-phenylalanyl chloromethyl ketone

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Insulin stimulates increased catalytic activity of phosphoinositide-dependent kinase-1 by a phosphorylation-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Mammalian TOR: a homeostatic ATP sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

PKC zeta enhances insulin-like growth factor 1-dependent mitogenic activity in the rat clonal beta cell line RIN 1046-38

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Autocrine regulation of growth in cultured human intestinal muscle by growth factors

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Endogenous IGF-I regulates IGF binding protein production in human intestinal smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Coupling of the insulin-like growth factor-I receptor tyrosine kinase to Gi2 in human intestinal smooth muscle: Gbetagamma -dependent mitogen-activated protein kinase activation and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Regulation of IGFBP-4 levels in human intestinal muscle by an IGF-I-activated, confluence-dependent protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Effect of mutations at serines 1280-1283 on the mitogenic and transforming activities of the insulin-like growth factor I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Dual requirement for a newly identified phosphorylation site in p70s6k

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

TOR, a central controller of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Rapamune® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Interleukin 3-dependent survival by the Akt protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Insulin activates protein kinases C-zeta and C-lambda by an autophosphorylation-dependent mechanism and stimulates their translocation to GLUT4 vesicles and other membrane fractions in rat adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Multiple independent inputs are required for activation of the p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinasein Vivoat Thr-412 as well as Thr-252

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.00310.2002

21 January 2018

Identifiers

DOI

10.1152/AJPGI.00310.2002

1 reference

1 December 2017

1 reference

PubMed ID

12444011