Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury (Q44016809)

29 November 2017

Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury (English)

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29 November 2017

adverse outcome pathway

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Imran Shah

5

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Mathieu Vinken

object named as

Mathieu Vinken

1

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Marina Goumenou

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Marina Goumenou

3

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author name string

Brigitte Landesmann

2

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29 November 2017

Stefanie Vinken

4

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29 November 2017

Hartmut Jaeschke

6

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29 November 2017

Catherine Willett

7

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29 November 2017

Maurice Whelan

8

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29 November 2017

Vera Rogiers

9

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29 November 2017

14 August 2013

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29 November 2017

Toxicological Sciences

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29 November 2017

136

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29 November 2017

1

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29 November 2017

97-106

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Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis

29 November 2017

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Toxicogenomics for transcription factor-governed molecular pathways: moving on to roles beyond classification and prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Bile acids as carcinogens in human gastrointestinal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Harmonization of cancer and noncancer risk assessment: proceedings of a consensus-building workshop

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Outcome and prognostic markers in severe drug-induced liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Developmental expression of canalicular transporter genes in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Regulation of hepatic bile acid transporters Ntcp and Bsep expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Novel orphan nuclear receptors-coregulator interactions controlling anti-cancer drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Molecular cloning and characterization of the murine bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Role of neutrophils in acute inflammatory liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Contribution of high basolateral bile salt efflux to the lack of hepatotoxicity in rat in response to drugs inducing cholestasis in human

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

The Key Events Dose-Response Framework: a cross-disciplinary mode-of-action based approach to examining dose-response and thresholds

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

De novo bile salt transporter antibodies as a possible cause of recurrent graft failure after liver transplantation: a novel mechanism of cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Suppression of DHEA sulfotransferase (Sult2A1) during the acute-phase response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

BSEP inhibition: in vitro screens to assess cholestatic potential of drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Use of dominant negative nuclear receptors to study xenobiotic-inducible gene expression in primary cultured hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

A framework for human relevance analysis of information on carcinogenic modes of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Role of breast cancer resistance protein in the adaptive response to cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Progressive familial intrahepatic cholestasis (PFIC) type 1, 2, and 3: a review of the liver pathology findings

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Hepatocanalicular transport defects: pathophysiologic mechanisms of rare diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

The current state of serum biomarkers of hepatotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Hepatobiliary transporters and drug-induced cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Human health safety evaluation of cosmetics in the EU: a legally imposed challenge to science

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Altered membrane fluidity in rat hepatocytes during endotoxic shock.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Oxidative stress is a triggering factor for LPS-induced Mrp2 internalization in the cryopreserved rat and human liver slices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Genomic responses in mouse models poorly mimic human inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Molecular pathogenesis of cholestasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Screening of repeated dose toxicity data present in SCC(NF)P/SCCS safety evaluations of cosmetic ingredients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

New molecular insights into the mechanisms of cholestasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Novel insight into mechanisms of cholestatic liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

An updated review on drug-induced cholestasis: mechanisms and investigation of physicochemical properties and pharmacokinetic parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Itraconazole-induced cholestasis: involvement of the inhibition of bile canalicular phospholipid translocator MDR3/ABCB4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Effect of bile duct ligation on bile acid composition in mouse serum and liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Molecular mechanisms of cholestasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Nuclear receptors as drug targets in cholestasis and drug-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

Inhibition of hepatocytary vesicular transport by cyclosporin A in the rat: relationship with cholestasis and hyperbilirubinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT177

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFT177

1 reference

29 November 2017

1 reference