Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development (Q39657434)

13 September 2017

Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development (English)

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13 September 2017

Ryan E Morgan

1

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13 September 2017

Michael Trauner

2

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13 September 2017

Carlo J van Staden

3

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13 September 2017

Paul H Lee

4

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13 September 2017

Bharath Ramachandran

5

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13 September 2017

Michael Eschenberg

6

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13 September 2017

Cynthia A Afshari

7

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13 September 2017

Charles W Qualls

8

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13 September 2017

Ruth Lightfoot-Dunn

9

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13 September 2017

Hisham K Hamadeh

10

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13 September 2017

9 September 2010

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13 September 2017

Toxicological Sciences

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13 September 2017

118

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13 September 2017

485-500

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13 September 2017

2

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Effect of cyclosporin A on the biliary excretion of cholephilic compounds in rats

13 September 2017

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Update on progressive familial intrahepatic cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Bile acid transporters: structure, function, regulation and pathophysiological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Inducing properties of rifabutin, and effects on the pharmacokinetics and metabolism of concomitant drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Bioactivation and hepatotoxicity of nitroaromatic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Mitochondrial abnormalities--a link to idiosyncratic drug hepatotoxicity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Multidrug resistance-associated proteins 3, 4, and 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

The human bile salt export pump: characterization of substrate specificity and identification of inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Missense mutations and single nucleotide polymorphisms in ABCB11 impair bile salt export pump processing and function or disrupt pre-messenger RNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Bile acids: regulation of synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Progressive familial intrahepatic cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

21 January 2018

Bile acid transporters

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Robust regression for high throughput drug screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Contribution of mrp2 in alterations of canalicular bile formation by the endothelin antagonist bosentan

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Hepatotoxicity and hepatic metabolism of available drugs: current problems and possible solutions in preclinical stages

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Adverse events associated with high-dose rifabutin in macrolide-containing regimens for the treatment of Mycobacterium avium complex lung disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Application of genomics for identification of systemic toxicity triggers associated with VEGF-R inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Mechanisms of acetaminophen-induced liver necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

The continuing importance of bile acids in liver and intestinal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Involvement of bile salt export pump in flutamide-induced cholestatic hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Mitochondrial dysfunction and delayed hepatotoxicity: another lesson from troglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

De novo bile salt transporter antibodies as a possible cause of recurrent graft failure after liver transplantation: a novel mechanism of cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Xenobiotic, bile acid, and cholesterol transporters: function and regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Transport, Metabolism, and Hepatotoxicity of Flutamide, Drug–Drug Interaction with Acetaminophen Involving Phase I and Phase II Metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

A patient with novel ABCB11 gene mutations with phenotypic transition between BRIC2 and PFIC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Drug-induced hepatotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Species-specific and age-dependent bile acid composition: aspects on CYP8B and CYP4A subfamilies in bile acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Drug-induced hepatotoxicity: 2005.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Postulated carbon tetrachloride mode of action: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Clinical hepatotoxicity. Regulation and treatment with inducers of transport and cofactors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Inhibition of bile acid transport across Na+/taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB 11)-coexpressing LLC-PK1 cells by cholestasis-inducing drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

The apical conjugate efflux pump ABCC2 (MRP2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Mitochondrially-mediated toxicity of bile acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Hepatocellular transporters and cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Hepatobiliary transporters and drug-induced cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Histological patterns in drug-induced liver disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Mitochondrially mediated synergistic cell killing by bile acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Technical pitfalls and improvements for high-speed screening and QSAR analysis to predict inhibitors of the human bile salt export pump (ABCB11/BSEP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Prediction of drug-induced intrahepatic cholestasis: in vitro screening and QSAR analysis of drugs inhibiting the human bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Effect of thiazolidinediones on bile acid transport in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

The bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Bile salt transporters: molecular characterization, function, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Evaluation of drug-transporter interactions using in vitro and in vivo models

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ269

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFQ269

1 reference

13 September 2017

1 reference