CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis (Q43594303)

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English	CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis	scientific article

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scholarly article

1 reference

Europe PubMed Central

25 November 2017

CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis (English)

1 reference

Europe PubMed Central

25 November 2017

apoptotic process

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based on heuristic

inferred from title

author name string

Bozyczko-Coyne D

1

1 reference

Europe PubMed Central

25 November 2017

O'Kane TM

2

1 reference

Europe PubMed Central

25 November 2017

Wu ZL

3

1 reference

Europe PubMed Central

25 November 2017

Dobrzanski P

4

1 reference

Europe PubMed Central

25 November 2017

Murthy S

5

1 reference

Europe PubMed Central

25 November 2017

Vaught JL

6

1 reference

Europe PubMed Central

25 November 2017

Scott RW

7

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Europe PubMed Central

25 November 2017

language of work or name

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publication date

1 May 2001

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Europe PubMed Central

25 November 2017

number of pages

15

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Journal of Neurochemistry

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Europe PubMed Central

25 November 2017

77

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Europe PubMed Central

25 November 2017

849-863

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Europe PubMed Central

25 November 2017

3

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Europe PubMed Central

25 November 2017

Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: association with pathology

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

CEP-1347/KT7515, a JNK pathway inhibitor, supports the in vitro survival of chick embryonic neurons.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Growth of a rat neuroblastoma cell line in serum-free supplemented medium

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Correlation between structure of Bcl-2 and its inhibitory function of JNK and caspase activity in dopaminergic neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Amyloid deposition is associated with c-Jun expression in Alzheimer's disease and amyloid angiopathy.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Activation of caspase-3 in beta-amyloid-induced apoptosis of cultured rat cortical neurons.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

An inhibitor of p38 and JNK MAP kinases prevents activation of caspase and apoptosis of cultured cerebellar granule neurons.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Distinct roles for sodium, chloride, and calcium in excitotoxic dendritic injury and recovery.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Beta-amyloid induces local neurite degeneration in cultured hippocampal neurons: evidence for neuritic apoptosis

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Cryopreservation of primary neurons for tissue culture.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

c-Jun contributes to amyloid beta-induced neuronal apoptosis but is not necessary for amyloid beta-induced c-jun induction.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

The jun and fos protein families are both required for cell cycle progression in fibroblasts

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Expression of polyglutamine-expanded Huntingtin activates the SEK1-JNK pathway and induces apoptosis in a hippocampal neuronal cell line

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Quantitative neuronal c-fos and c-jun expression in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Calpain and calpastatin in normal and Alzheimer-degenerated human brain tissue.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Preservation of cholinergic activity and prevention of neuron death by CEP-1347/KT-7515 following excitotoxic injury of the nucleus basalis magnocellularis.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Amyloid beta-induced neuronal death is bax-dependent but caspase-independent.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Heparan sulfate and chondroitin sulfate glycosaminoglycan attenuate beta-amyloid(25-35) induced neurodegeneration in cultured hippocampal neurons.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00294.X

21 January 2018

Identifiers

10.1046/J.1471-4159.2001.00294.X

1 reference

Europe PubMed Central

25 November 2017

1 reference

Europe PubMed Central

25 November 2017

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