Amyloid beta-induced neuronal death is bax-dependent but caspase-independent (Q53234217)

12 May 2018

title

Amyloid beta-induced neuronal death is bax-dependent but caspase-independent (English)

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12 May 2018

4

Rakic P

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12 May 2018

3

Flavell RA

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12 May 2018

author name string

Selznick LA

series ordinal

1

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12 May 2018

Zheng TS

series ordinal

2

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12 May 2018

Roth KA

series ordinal

5

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12 May 2018

publication date

1 April 2000

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12 May 2018

Journal of Neuropathology & Experimental Neurology

published in

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12 May 2018

volume

59

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12 May 2018

issue

4

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12 May 2018

page(s)

271-279

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12 May 2018

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Hydrogen peroxide mediates amyloid beta protein toxicity

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Ultrastructural analysis of beta-amyloid-induced apoptosis in cultured hippocampal neurons

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Delayed behavioral effects following intrahippocampal injection of aggregated A beta (1-42).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Expression of ced-3 and ced-9 homologs in Alzheimer"s disease cerebral cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

BAX is required for neuronal death after trophic factor deprivation and during development

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL.

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Differential requirement for caspase 9 in apoptotic pathways in vivo.

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Emerging roles of caspase-3 in apoptosis

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Mitochondria and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Cholera toxin binds to differentiating neurons in the developing murine basal ganglia

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Trophic support promotes survival of bcl-x-deficient telencephalic cells in vitro

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Making sense of the multiple MAP-2 transcripts and their role in the neuron

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Calpain-mediated proteolysis of microtubule associated proteins MAP1B and MAP2 in developing brain

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Neuroprotective action of cycloheximide involves induction of bcl-2 and antioxidant pathways

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Multiple pathways of apoptosis in PC12 cells. CrmA inhibits apoptosis induced by beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: relevance to Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Inhibitors of interleukin-1β-converting enzyme-family proteases (caspases) prevent apoptosis without affecting decreased cellular ability to reduce 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide in cerebellar granule neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer's disease hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Bcl-2 and Bax protein expression in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Apoptosis. Dead end for neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Calpain inhibition: an overview of its therapeutic potential

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Microtubule stabilizing drugs for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.4.271

21 January 2018

Identifiers

DOI

10.1093/JNEN/59.4.271

1 reference

12 May 2018

1 reference

12 May 2018