Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models (Q43494697)

24 November 2017

Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models (English)

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24 November 2017

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6

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2

Chiara Zuccato

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author name string

Paola Conforti

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24 November 2017

Germano Gaudenzi

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24 November 2017

Alessandro Ieraci

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24 November 2017

Stefano Camnasio

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24 November 2017

Cesare Mutti

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24 November 2017

Franco Cotelli

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24 November 2017

language of work or name

English

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publication date

19 July 2013

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Journal of Neurochemistry

24 November 2017

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24 November 2017

127

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1

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24 November 2017

22-35

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Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study

24 November 2017

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The repressor element 1-silencing transcription factor regulates heart-specific gene expression using multiple chromatin-modifying complexes

21 January 2018

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Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease

21 January 2018

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Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin

21 January 2018

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Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes

21 January 2018

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The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease

21 January 2018

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DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome

21 January 2018

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The Amber biomolecular simulation programs

21 January 2018

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In vivo delivery of DN:REST improves transcriptional changes of REST-regulated genes in HD mice

21 January 2018

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Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death

21 January 2018

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Transcriptional regulation: cancer, neurons and the REST

21 January 2018

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Decreased BDNF levels are a major contributor to the embryonic phenotype of huntingtin knockdown zebrafish.

21 January 2018

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A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations

21 January 2018

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Virtual screening approach for the identification of new Rac1 inhibitors

21 January 2018

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Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons

21 January 2018

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2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure

21 January 2018

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H++: a server for estimating pKas and adding missing hydrogens to macromolecules

21 January 2018

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RE1 Silencing transcription factor maintains a repressive chromatin environment in embryonic hippocampal neural stem cells.

21 January 2018

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The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex

21 January 2018

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

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ZINC--a free database of commercially available compounds for virtual screening

21 January 2018

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Gene dysregulation in Huntington's disease: REST, microRNAs and beyond

21 January 2018

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Genome-wide mapping of in vivo protein-DNA interactions

21 January 2018

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The neuronal repressor REST/NRSF is an essential regulator in medulloblastoma cells.

21 January 2018

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SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington's disease

21 January 2018

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DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome.

21 January 2018

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An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin

21 January 2018

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Expression and functions of the repressor element 1 (RE-1)-silencing transcription factor (REST) in breast cancer

21 January 2018

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Analysis of the repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy of non-neuronal genes in peripheral lymphocytes from patients with Huntington's disease

21 January 2018

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AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

21 January 2018

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Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes

21 January 2018

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Ensemble Docking from Homology Models.

21 January 2018

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Chromatin crosstalk in development and disease: lessons from REST

21 January 2018

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UCSF Chimera--a visualization system for exploratory research and analysis

21 January 2018

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Loss of huntingtin function complemented by small molecules acting as repressor element 1/neuron restrictive silencer element silencer modulators

21 January 2018

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Turning REST/NRSF dysfunction in Huntington's disease into a pharmaceutical target

21 January 2018

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Transcriptional repression by neuron-restrictive silencer factor is mediated via the Sin3-histone deacetylase complex

21 January 2018

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Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued

21 January 2018

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Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington's disease

21 January 2018

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Distinct profiles of REST interactions with its target genes at different stages of neuronal development

21 January 2018

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Pharmacologic approaches to the treatment of Huntington's disease

21 January 2018

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A genetic screen for candidate tumor suppressors identifies REST

21 January 2018

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Role of brain-derived neurotrophic factor in Huntington's disease

21 January 2018

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Brain-derived neurotrophic factor in neurodegenerative diseases

21 January 2018

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Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

21 January 2018

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Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.

21 January 2018

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Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease

21 January 2018

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Molecular mechanisms and potential therapeutical targets in Huntington's disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JNC.12348

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release_vgo6ihml7zedjemqokcxb5vxey

24 November 2017

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Fatcat

https://api.fatcat.wiki/v0/release/vgo6ihml7zedjemqokcxb5vxey

mapped directly with Wikidata item

24 November 2022

based on heuristic

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