An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin (Q47073933)

5 January 2018

title

An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin (English)

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5 January 2018

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13

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Elena Cattaneo

17

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Chiara Zuccato

2

Chiara Zuccato

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Marta Valenza

Marta Valenza

11

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Anna Pistocchi

Anna Pistocchi

9

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Luciano Conti

Luciano Conti

10

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James F. Gusella

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James Gusella

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5 January 2018

author name string

Valentina Lo Sardo

1

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Germano Gaudenzi

3

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Barbara Vitali

4

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Catarina Ramos

5

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Marzia Tartari

6

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Michael A Myre

7

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James A Walker

8

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Binia Drung

12

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Scott Zeitlin

15

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Franco Cotelli

16

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language of work or name

English

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publication date

1 May 2012

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5 January 2018

published in

Nature Neuroscience

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5 January 2018

volume

15

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5 January 2018

page(s)

713-721

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5 January 2018

issue

5

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5 January 2018

https://scigraph.springernature.com/pub.10.1038/nn.3080

exact match

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cites work

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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Phylogenetic comparison of huntingtin homologues reveals the appearance of a primitive polyQ in sea urchin.

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Detection of alpha-rod protein repeats using a neural network and application to huntingtin.

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Deficiency of huntingtin has pleiotropic effects in the social amoeba Dictyostelium discoideum

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Molecular mechanisms and potential therapeutical targets in Huntington's disease

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Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

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Depletion of wild-type huntingtin in mouse models of neurologic diseases

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Wild-type huntingtin protects neurons from excitotoxicity

21 January 2018

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Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing

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Wild type Huntingtin reduces the cellular toxicity of mutant Huntingtin in mammalian cell models of Huntington's disease

21 January 2018

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Inactivation of the mouse Huntington's disease gene homolog Hdh

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Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

21 January 2018

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Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

21 January 2018

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Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

21 January 2018

1 reference

The HD mutation causes progressive lethal neurological disease in mice expressing reduced levels of huntingtin.

21 January 2018

1 reference

Selective neuronal requirement for huntingtin in the developing zebrafish

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Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis

21 January 2018

1 reference

Neural differentiation of embryonic stem cells in vitro: a road map to neurogenesis in the embryo

21 January 2018

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Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage

21 January 2018

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Improved synthesis of ADAM10 inhibitor GI254023X.

21 January 2018

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Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture

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Decreased BDNF levels are a major contributor to the embryonic phenotype of huntingtin knockdown zebrafish.

21 January 2018

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Involvement of wnt1 and pax2 in the formation of the midbrain-hindbrain boundary in the zebrafish gastrula

21 January 2018

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atoh1.2 and beta3.1 are two new bHLH-encoding genes expressed in selective precursor cells of the zebrafish anterior hindbrain

21 January 2018

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Cadherins in development: cell adhesion, sorting, and tissue morphogenesis

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Developmental defects in mouse embryos lacking N-cadherin

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ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling

21 January 2018

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

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Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity

21 January 2018

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Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage

21 January 2018

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Characterization of sequential N-cadherin cleavage by ADAM10 and PS1.

21 January 2018

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A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice

21 January 2018

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Targeting of retinal axons requires the metalloproteinase ADAM10.

21 January 2018

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Huntingtin inhibits caspase-3 activation

21 January 2018

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The ADAMs family: coordinators of nervous system development, plasticity and repair

21 January 2018

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RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity.

21 January 2018

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A putative Drosophila homolog of the Huntington's disease gene

21 January 2018

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Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model

21 January 2018

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Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease

21 January 2018

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A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

21 January 2018

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Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice

21 January 2018

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Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis

21 January 2018

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Neuronal degeneration in the basal ganglia and loss of pallido-subthalamic synapses in mice with targeted disruption of the Huntington's disease gene

21 January 2018

2 references

21 January 2018

12 December 2020

Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos

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12 December 2020

parachute/n-cadherin is required for morphogenesis and maintained integrity of the zebrafish neural tube

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12 December 2020

Expression of normal and mutant huntingtin in the developing brain

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12 December 2020

Neurons lacking huntingtin differentially colonize brain and survive in chimeric mice

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12 December 2020

Whole-mount in situ hybridizations on zebrafish embryos using a mixture of digoxigenin- and fluorescein-labelled probes

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12 December 2020

Wild-type huntingtin protects from apoptosis upstream of caspase-3.

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12 December 2020

Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues.

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12 December 2020

Identifiers

DOI

10.1038/NN.3080

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5 January 2018

PubMed ID

22466506

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5 January 2018