Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis. (Q43116152)

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29 January 2020

title

Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis (English)

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29 January 2020

1

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29 January 2020

Fernanda Ortis

3

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29 January 2020

Stephan Lortz

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author name string

F Christulia

2

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P Pirot

4

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29 January 2020

S Lenzen

6

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D L Eizirik

7

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A K Cardozo

8

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29 January 2020

publication date

29 March 2010

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29 January 2020

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volume

53

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issue

6

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29 January 2020

page(s)

1120-1130

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https://scigraph.springernature.com/pub.10.1007/s00125-010-1699-7

29 January 2020

exact match

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Glucose regulation of insulin gene expression in pancreatic beta-cells

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Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis

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Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs

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Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

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Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms

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Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells.

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XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands

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Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells

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The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells

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XBP1 is critical to protect cells from endoplasmic reticulum stress: evidence from Site-2 protease-deficient Chinese hamster ovary cells.

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The role for endoplasmic reticulum stress in diabetes mellitus

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Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells

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Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1

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Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells

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Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.

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Preventing oxidative stress: a new role for XBP1.

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Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells

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Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

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Mitochondrial membrane permeabilization in cell death

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Unconventional splicing of XBP-1 mRNA in the unfolded protein response

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Expression of neuronal traits in pancreatic beta cells. Implication of neuron-restrictive silencing factor/repressor element silencing transcription factor, a neuron-restrictive silencer.

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12 December 2020

Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays

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Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway

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12 December 2020

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

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Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets

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High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

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Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

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IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

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Protective effect against Parkinson's disease-related insults through the activation of XBP1

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Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation

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12 December 2020

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12 December 2020

PDX-1 and MafA play a crucial role in pancreatic beta-cell differentiation and maintenance of mature beta-cell function

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12 December 2020

Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II

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12 December 2020