PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy (Q42922896)

11 November 2017

title

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy (English)

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M Porru

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Carlo Leonetti

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C Leonetti

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author name string

M Scarsella

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S Iachettini

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L Tentori

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G Graziani

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M F G Stevens

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D Passeri

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E Gilson

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G Zupi

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language of work or name

English

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publication date

30 August 2010

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11 November 2017

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volume

29

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issue

47

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page(s)

6280-6293

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https://scigraph.springernature.com/pub.10.1038/onc.2010.344

11 November 2017

exact match

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cites work

PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase

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TRF2 inhibition promotes anchorage-independent growth of telomerase-positive human fibroblasts.

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Detection of poly(ADP-ribose) polymerase activation in oxidatively stressed cells and tissues using biotinylated NAD substrate

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Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2.

21 January 2018

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A DNA damage checkpoint response in telomere-initiated senescence

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Shelterin: the protein complex that shapes and safeguards human telomeres

21 January 2018

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The role of the poly(ADP-ribose) polymerase tankyrase1 in telomere length control by the TRF1 component of the shelterin complex

21 January 2018

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat

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The expanding role of poly(ADP-ribose) metabolism: current challenges and new perspectives.

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PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres

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Mammalian telomeres end in a large duplex loop

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Antitumor polycyclic acridines. 8.(1) Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts

21 January 2018

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TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression

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Targeting the limitless replicative potential of cancer: the telomerase/telomere pathway

21 January 2018

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The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair

21 January 2018

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G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors.

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Targeted therapy for cancer using PARP inhibitors

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Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

21 January 2018

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Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

21 January 2018

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The role of poly(ADP-ribose) in the DNA damage signaling network

21 January 2018

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Increased melanoma growth and metastasis spreading in mice overexpressing placenta growth factor.

21 January 2018

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Physiological relevance of telomeric G-quadruplex formation: a potential drug target

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Stem cell marker expression and proliferation and apoptosis of vascular smooth muscle cells

21 January 2018

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Targeting poly(ADP-ribose) polymerase: a two-armed strategy for cancer therapy

21 January 2018

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Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.

21 January 2018

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Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology

21 January 2018

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Functional characterization of the poly(ADP-ribose) polymerase activity of tankyrase 1, a potential regulator of telomere length

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.344

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

21 January 2018

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Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1

21 January 2018

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Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.344

PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.344

DNA damage foci at dysfunctional telomeres

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.344

Chemopotentiation by PARP inhibitors in cancer therapy.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.344

Normal human chromosomes have long G-rich telomeric overhangs at one end

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.344

Reconstitution of hTERT restores tumorigenicity in melanoma-derived c-Myc low-expressing clones

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.344

Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.344

Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.344

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.344

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Dimensions Publication ID

11 November 2017

1037313551

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