TRF2 inhibition promotes anchorage-independent growth of telomerase-positive human fibroblasts. (Q40365410)

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7 January 2020

title

TRF2 inhibition promotes anchorage-independent growth of telomerase-positive human fibroblasts (English)

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12

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author name string

Brunori M

1

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7 January 2020

Mathieu N

2

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Ricoul M

3

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Bauwens S

4

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Koering CE

5

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Roborel de Climens A

6

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Belleville A

7

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Wang Q

8

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Puisieux I

9

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Décimo D

10

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Puisieux A

11

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Gilson E

13

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language of work or name

English

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publication date

1 February 2006

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volume

25

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7 January 2020

page(s)

990-997

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issue

7

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209135

7 January 2020

exact match

0 references

cites work

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Constitutive telomerase expression promotes mammary carcinomas in aging mice

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Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

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Telomeric localization of TRF2, a novel human telobox protein

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Extension of life-span by introduction of telomerase into normal human cells

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Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage.

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Telomere dysfunction in genome instability syndromes.

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In situ analyses of genome instability in breast cancer

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p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

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Telomere biology: a new player in the end zone.

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The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle

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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

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Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

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Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

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Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

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Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

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Creation of human tumour cells with defined genetic elements

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Enumeration of the simian virus 40 early region elements necessary for human cell transformation

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Inhibition of telomerase limits the growth of human cancer cells.

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p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

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The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

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Senescence Induced by Altered Telomere State, Not Telomere Loss

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DNA damage transiently increases TRF2 mRNA expression and telomerase activity

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Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity

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21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Species- and cell type-specific requirements for cellular transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209135

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1209135

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16205637%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

7 January 2020

0 references

1 reference