Constitutive activation of the Raf-MAPK pathway causes negative feedback inhibition of Ras-PI3K-AKT and cellular arrest through the EphA2 receptor (Q42819727)

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scientific article published on 3 December 2007

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English	Constitutive activation of the Raf-MAPK pathway causes negative feedback inhibition of Ras-PI3K-AKT and cellular arrest through the EphA2 receptor	scientific article published on 3 December 2007

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scholarly article

1 reference

Europe PubMed Central

8 November 2017

Constitutive activation of the Raf-MAPK pathway causes negative feedback inhibition of Ras-PI3K-AKT and cellular arrest through the EphA2 receptor (English)

1 reference

Europe PubMed Central

8 November 2017

author name string

Menges CW

1

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Europe PubMed Central

8 November 2017

McCance DJ

2

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Europe PubMed Central

8 November 2017

language of work or name

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publication date

3 December 2007

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Europe PubMed Central

8 November 2017

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Europe PubMed Central

8 November 2017

27

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Europe PubMed Central

8 November 2017

20

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Europe PubMed Central

8 November 2017

2934-2940

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Europe PubMed Central

8 November 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1210957

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Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

PKB binding proteins. Getting in on the Akt.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Mechanisms of regulating the Raf kinase family

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

A negative feedback signaling network underlies oncogene-induced senescence

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Insulin stimulation of a MEK-dependent but ERK-independent SOS protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI3K/Akt pathway in differentiating intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

A conditional feedback loop regulates Ras activity through EphA2.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

PKB/AKT: functional insights from genetic models

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Mek1 alters epidermal growth and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

AKT1 provides an essential survival signal required for differentiation and stratification of primary human keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Differential regulation of EphA2 in normal and malignant cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

E7 abolishes raf-induced arrest via mislocalization of p21(Cip1).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210957

21 January 2018

Identifiers

10.1038/SJ.ONC.1210957

1 reference

Europe PubMed Central

8 November 2017

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1 reference

Europe PubMed Central

8 November 2017

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