Combination of drug therapy in acute lymphoblastic leukemia with a CXCR4 antagonist (Q42803194)

7 November 2017

Combination of drug therapy in acute lymphoblastic leukemia with a CXCR4 antagonist (English)

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7 November 2017

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lymphoblastic leukemia

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R Parameswaran

1

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7 November 2017

M Yu

2

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7 November 2017

M Lim

3

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7 November 2017

J Groffen

4

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7 November 2017

N Heisterkamp

5

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7 November 2017

12 April 2011

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7 November 2017

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7 November 2017

25

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7 November 2017

8

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7 November 2017

1314-1323

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https://scigraph.springernature.com/pub.10.1038/leu.2011.76

7 November 2017

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Novel therapies for relapsed acute lymphoblastic leukemia

27 May 2018

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Activity of the Aurora kinase inhibitor VX-680 against Bcr/Abl-positive acute lymphoblastic leukemias

27 May 2018

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Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4/CXCL12 axis

27 May 2018

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Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to Imatinib and Nilotinib

27 May 2018

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CXCR4 mediates the homing of B cell progenitor acute lymphoblastic leukaemia cells to the bone marrow via activation of p38MAPK.

27 May 2018

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Proof of activity with AMD11070, an orally bioavailable inhibitor of CXCR4-tropic HIV type 1.

27 May 2018

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Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100.

27 May 2018

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CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers

27 May 2018

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Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.

27 May 2018

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The CXCR4 antagonist AMD3100 impairs survival of human AML cells and induces their differentiation

27 May 2018

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Comparison of the potential multiple binding modes of bicyclam, monocylam, and noncyclam small-molecule CXC chemokine receptor 4 inhibitors

27 May 2018

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Nilotinib treatment in mouse models of P190 Bcr/Abl lymphoblastic leukemia

27 May 2018

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Multiple-dose escalation study of the safety, pharmacokinetics, and biologic activity of oral AMD070, a selective CXCR4 receptor inhibitor, in human subjects

27 May 2018

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Resistance to imatinib of bcr/abl p190 lymphoblastic leukemia cells

27 May 2018

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Microenvironmental niches in the bone marrow required for B-cell development

27 May 2018

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Treatment of acute lymphoblastic leukemia

27 May 2018

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Childhood acute lymphoblastic leukaemia and relapse

27 May 2018

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CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment

27 May 2018

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Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis

27 May 2018

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Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

27 May 2018

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Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling

27 May 2018

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27 May 2018

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A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo

27 May 2018

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A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias

27 May 2018

1 reference

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Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

27 May 2018

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Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function

27 May 2018

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Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers

27 May 2018

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Effects of the chemokine stromal cell-derived factor-1 on the migration and localization of precursor-B acute lymphoblastic leukemia cells within bone marrow stromal layers.

27 May 2018

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Inhibition of HIV infection by bicyclams, highly potent and specific CXCR4 antagonists

27 May 2018

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Selective secretion of chemoattractants for haemopoietic progenitor cells by bone marrow endothelial cells: a possible role in homing of haemopoietic progenitor cells to bone marrow

27 May 2018

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Molecular cloning and structure of a pre-B-cell growth-stimulating factor

27 May 2018

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Inhibition of the SDF-1alpha-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice.

27 May 2018

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A pilot study of continuous imatinib vs pulsed imatinib with or without G-CSF in CML patients who have achieved a complete cytogenetic response.

27 May 2018

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Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells.

16 August 2018

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Rapid mobilization of CD34+ cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple myeloma and non-Hodgkin's lymphoma.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135709

High expression of the chemokine receptor CXCR4 predicts extramedullary organ infiltration in childhood acute lymphoblastic leukaemia.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135709

Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135709

A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma

16 August 2018

1 reference

12 December 2020

Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro

1 reference

12 December 2020

The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases

1 reference

12 December 2020

Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist

1 reference

12 December 2020

Treatment of late bone marrow relapse in children with acute lymphoblastic leukemia: a Pediatric Oncology Group study

1 reference

12 December 2020

Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells

1 reference

12 December 2020

Long-term survival and proliferation of precursor-B acute lymphoblastic leukemia cells on human bone marrow stroma

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12 December 2020

Good engraftment of B-cell precursor ALL in NOD-SCID mice

1 reference

12 December 2020

Expression of CXCR4 Predicts Poor Prognosis in Patients with Malignant Melanoma

1 reference

12 December 2020

Defective p38 mitogen-activated protein kinase signaling impairs chemotaxic but not proliferative responses to stromal-derived factor-1alpha in acute lymphoblastic leukemia

1 reference

12 December 2020

Identifiers

DOI

10.1038/LEU.2011.76

1 reference

Dimensions Publication ID

7 November 2017

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7 November 2017

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