The CXCR4 antagonist AMD3100 impairs survival of human AML cells and induces their differentiation (Q39943574)

15 September 2017

The CXCR4 antagonist AMD3100 impairs survival of human AML cells and induces their differentiation (English)

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N Amariglio

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G Rechavi

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J Jacob-Hirsch

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M Eisenbach

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T Golan

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I Petit

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S Kay

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S Baron

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V Deutsch

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E Naparstek

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https://scigraph.springernature.com/pub.10.1038/leu.2008.238

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Ligation of the CD44 adhesion molecule reverses blockage of differentiation in human acute myeloid leukemia

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The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood.

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Rapid and efficient homing of human CD34(+)CD38(-/low)CXCR4(+) stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice

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A highly sensitive strategy for SCID-repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD/SCID mice bone marrow

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CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice

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Stromal cell-derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G(0)/G(1) transition in CD34(+) cells: evidence for an autocrine/paracrine mechanism.

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Motility, proliferation, and egress to the circulation of human AML cells are elastase dependent in NOD/SCID chimeric mice

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Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches

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Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias.

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Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia

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Targeting of CD44 eradicates human acute myeloid leukemic stem cells

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Functional response of leukaemic blasts to stromal cell-derived factor-1 correlates with preferential expression of the chemokine receptor CXCR4 in acute myelomonocytic and lymphoblastic leukaemia

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Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype

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7 January 2021

Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter

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7 January 2021

Effects of AMD3100 on transmigration and survival of acute myelogenous leukemia cells

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https://api.crossref.org/works/10.1038%2FLEU.2008.238

7 January 2021

Identifiers

DOI

10.1038/LEU.2008.238

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15 September 2017

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