The proapoptotic dp5 gene is a direct target of the MLK-JNK-c-Jun pathway in sympathetic neurons (Q42199081)

18 October 2017

The proapoptotic dp5 gene is a direct target of the MLK-JNK-c-Jun pathway in sympathetic neurons (English)

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18 October 2017

Emily Towers

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18 October 2017

Jonathan Gilley

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18 October 2017

Rebecca Randall

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18 October 2017

Rosie Hughes

4

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18 October 2017

Mark Kristiansen

5

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18 October 2017

Jonathan Ham

6

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18 October 2017

20 March 2009

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18 October 2017

Nucleic Acids Research

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18 October 2017

37

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18 October 2017

9

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18 October 2017

3044-3060

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describes a project that uses

18 October 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2685101/fullTextXML

inferred from PubMed Central ID database lookup

cites work

dp5/HRK is a c-Jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neurons

1 reference

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Life in the balance: how BH3-only proteins induce apoptosis.

26 October 2017

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The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis: identification of the nuclear pore complex as a potential target of the JNK pathway.

26 October 2017

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Cell death: critical control points

26 October 2017

1 reference

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c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation

26 October 2017

1 reference

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Evidence for a role of mixed lineage kinases in neuronal apoptosis

26 October 2017

1 reference

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Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

26 October 2017

1 reference

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Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

26 October 2017

1 reference

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Signal transduction by the JNK group of MAP kinases

26 October 2017

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Apoptosis in the nervous system

26 October 2017

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Neurotrophin signal transduction in the nervous system

26 October 2017

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The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein

26 October 2017

1 reference

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Autocrine growth and anchorage independence: two complementing Jun-controlled genetic programs of cellular transformation.

26 October 2017

1 reference

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Programmed cell death in neurons: focus on the pathway of nerve growth factor deprivation-induced death of sympathetic neurons.

26 October 2017

1 reference

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BAX is required for neuronal death after trophic factor deprivation and during development

26 October 2017

1 reference

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Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

26 October 2017

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Role of BCL-2 in the survival and function of developing and mature sympathetic neurons

26 October 2017

1 reference

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

26 October 2017

1 reference

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Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation

26 October 2017

1 reference

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Cell death during development of the nervous system

26 October 2017

1 reference

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BH3-only proteins: key regulators of neuronal apoptosis

26 October 2017

1 reference

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Quantification of transcriptional activities of reporter gene constructs in primary cultures of sympathetic neurons.

29 May 2018

1 reference

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Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation

29 May 2018

1 reference

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Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons.

29 May 2018

1 reference

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Comparison between the timing of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685101

Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death

29 May 2018

1 reference

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A system for characterizing cellular and molecular events in programmed neuronal cell death.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685101

Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685101

Methods for culturing primary sympathetic neurons and for determining neuronal viability

17 August 2018

1 reference

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FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685101

JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685101

CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685101

Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685101

Direct inhibition of c-Jun N-terminal kinase in sympathetic neurones prevents c-jun promoter activation and NGF withdrawal-induced death.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685101

Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685101

Function and expression of the Bcl-x gene in the developing and adult nervous system.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685101

Binding of promoter-associated AP-1 is not altered during induction and subsequent repression of the c-jun promoter by TPA and UV irradiation.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685101

Pro-apoptotic Bim Induction in Response to Nerve Growth Factor Deprivation Requires Simultaneous Activation of Three Different Death Signaling Pathways

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685101

Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene

1 December 2018

1 reference

12 December 2020

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

1 reference

12 December 2020

Mixed-lineage kinase inhibitors require the activation of Trk receptors to maintain long-term neuronal trophism and survival

1 reference

12 December 2020

CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults

1 reference

12 December 2020

Inhibition of JNK by overexpression of the JNL binding domain of JIP-1 prevents apoptosis in sympathetic neurons

1 reference

12 December 2020

BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/GKP175

1 reference

18 October 2017

1 reference

18 October 2017

1 reference