Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic β-cells (Q42152165)

17 October 2017

Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic β-cells (English)

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17 October 2017

Jun Shirakawa

1

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author name string

Yu Togashi

2

1 reference

17 October 2017

Eri Sakamoto

3

1 reference

17 October 2017

Mitsuyo Kaji

4

1 reference

17 October 2017

Kazuki Tajima

5

1 reference

17 October 2017

Kazuki Orime

6

1 reference

17 October 2017

Hideaki Inoue

7

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17 October 2017

Naoto Kubota

8

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17 October 2017

Takashi Kadowaki

9

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17 October 2017

Yasuo Terauchi

10

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17 October 2017

language of work or name

English

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publication date

25 June 2013

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17 October 2017

11

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based on heuristic

inferred from page(s)

published in

Diabetes

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17 October 2017

62

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17 October 2017

3448-3458

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17 October 2017

10

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

17 October 2017

start time

28 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Chronic treatment with a glucokinase activator delays the onset of hyperglycaemia and preserves beta cell mass in the Zucker diabetic fatty rat.

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Effects of MK-0941, a novel glucokinase activator, on glycemic control in insulin-treated patients with type 2 diabetes

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Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet β-cells

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Stanniocalcin 2 alters PERK signalling and reduces cellular injury during cerulein induced pancreatitis in mice

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Glucose and aging control the quiescence period that follows pancreatic beta cell replication

29 May 2018

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ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis

29 May 2018

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Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress

29 May 2018

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Effects of glucokinase activators GKA50 and LY2121260 on proliferation and apoptosis in pancreatic INS-1 beta cells

29 May 2018

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Assessing the potential of glucokinase activators in diabetes therapy

29 May 2018

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Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

29 May 2018

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Crucial roles of neuronatin in insulin secretion and high glucose-induced apoptosis in pancreatic beta-cells

29 May 2018

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Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance

29 May 2018

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Dual role of proapoptotic BAD in insulin secretion and beta cell survival

29 May 2018

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The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis

29 May 2018

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The role for endoplasmic reticulum stress in diabetes mellitus

29 May 2018

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Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells.

29 May 2018

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29 May 2018

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Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance

29 May 2018

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Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

29 May 2018

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Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.

29 May 2018

1 reference

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An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism

29 May 2018

1 reference

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Inhibition of glucose-stimulated activation of extracellular signal-regulated protein kinases 1 and 2 by epinephrine in pancreatic beta-cells

29 May 2018

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Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells

29 May 2018

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Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells

29 May 2018

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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

29 May 2018

1 reference

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Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death

29 May 2018

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Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications

29 May 2018

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Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes

29 May 2018

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cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.

29 May 2018

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

29 May 2018

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Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781485

Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781485

A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781485

Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781485

Glucokinase as pancreatic beta cell glucose sensor and diabetes gene

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781485

Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781485

Effects of liraglutide on β-cell-specific glucokinase-deficient neonatal mice.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781485

Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781485

Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781485

Control of pancreatic β cell regeneration by glucose metabolism.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781485

Structure-activity relationships of 3,5-disubstituted benzamides as glucokinase activators with potent in vivo efficacy.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781485

Impact of small-molecule glucokinase activator on glucose metabolism and beta-cell mass

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781485

High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunction

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781485

A novel glucokinase activator modulates pancreatic islet and hepatocyte function

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781485

Allosteric activators of glucokinase: potential role in diabetes therapy

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781485

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781485

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781485

Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23801577

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2337/DB13-0052

1 reference

17 October 2017

1 reference

17 October 2017

1 reference