The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3 (Q42077037)

16 October 2017

The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3 (English)

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16 October 2017

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2

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16 October 2017

Cecile Terrenoire

1

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16 October 2017

George S Baillie

series ordinal

3

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16 October 2017

Robert S Kass

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4

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16 October 2017

language of work or name

English

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publication date

13 February 2009

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Journal of Biological Chemistry

16 October 2017

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16 October 2017

284

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16 October 2017

14

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16 October 2017

9140-9146

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describes a project that uses

16 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2666564/fullTextXML

inferred from PubMed Central ID database lookup

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RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

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In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region

30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

30 May 2018

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Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area

30 May 2018

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PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

30 May 2018

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Characterization of the cyclic nucleotide phosphodiesterase subtypes involved in the regulation of the L-type Ca2+ current in rat ventricular myocytes.

30 May 2018

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Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450

30 May 2018

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Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

30 May 2018

1 reference

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Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666564

K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666564

Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation

30 May 2018

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The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666564

A uniform enzymatic method for dissociation of myocytes from hearts and stomachs of vertebrates.

30 May 2018

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Phosphodiesterase inhibition in ventricular cardiomyocytes from guinea-pig hearts

30 May 2018

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Adrenergic regulation of a key cardiac potassium channel can contribute to atrial fibrillation: evidence from an I Ks transgenic mouse

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666564

Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666564

De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in utero.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666564

Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666564

Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666564

Contribution of phosphodiesterase isozymes to the regulation of the L-type calcium current in human cardiac myocytes

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666564

MinK-KvLQT1 fusion proteins, evidence for multiple stoichiometries of the assembled IsK channel

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19218243

12 December 2020

inferred from PubMed ID database lookup

The ionic basis of concentration-related effects of noradrenaline on the action potential of calf cardiac purkinje fibres

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19218243

12 December 2020

inferred from PubMed ID database lookup

Regulation of a heart potassium channel by protein kinase A and C

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19218243

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M805366200

1 reference

16 October 2017

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16 October 2017

1 reference