The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins (Q40633113)

22 September 2017

The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins (English)

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22 September 2017

7

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22 September 2017

Graeme B Bolger

1

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22 September 2017

Angela McCahill

2

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22 September 2017

Elaine Huston

3

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22 September 2017

York-Fong Cheung

4

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22 September 2017

Theresa McSorley

5

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22 September 2017

George S Baillie

6

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22 September 2017

language of work or name

English

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publication date

18 September 2003

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Journal of Biological Chemistry

22 September 2017

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22 September 2017

278

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22 September 2017

49230-49238

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22 September 2017

49

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Complexity and diversity of mammalian adenylyl cyclases

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Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization

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Seven-transmembrane receptors

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G protein-coupled receptor signalling and cross-talk: achieving rapidity and specificity

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G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction

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Beta-Arrestins: new roles in regulating heptahelical receptors' functions

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Arresting developments in heptahelical receptor signaling and regulation

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beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation

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Cyclic nucleotide research -- still expanding after half a century

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Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.

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PDE4 cAMP-specific phosphodiesterases

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PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

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Recent advances in PDE4 inhibitors as immunoregulators and anti-inflammatory drugs

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Phosphodiesterase 4 inhibitors and the treatment of asthma: where are we now and where do we go from here?

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A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

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Activation of the cAMP-specific phosphodiesterase PDE4D3 by phosphorylation. Identification and function of an inhibitory domain

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UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions.

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Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins

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beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi

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Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

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Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3

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Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes

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Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition

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Ligand regulation of green fluorescent protein-tagged forms of the human beta(1)- and beta(2)-adrenoceptors; comparisons with the unmodified receptors

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The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform

21 January 2018

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Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein

21 January 2018

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Activation of the mitogen-activated protein kinase cascade by pertussis toxin-sensitive and -insensitive pathways in cultured ventricular cardiomyocytes

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Inhibition of inducible nitric oxide synthase expression by interleukin-4 and interleukin-13 in human lung epithelial cells

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cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: generation of a molecular model.

21 January 2018

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A peripheral and an intrinsic enzyme constitute the cyclic AMP phosphodiesterase activity of rat liver plasma membranes

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Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells

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Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity.

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Regulation of G protein-coupled receptor signaling by scaffold proteins

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Crystal structure of beta-arrestin at 1.9 A: possible mechanism of receptor binding and membrane Translocation

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Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3

21 January 2018

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Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.

21 January 2018

1 reference

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Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

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Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation

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Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

21 January 2018

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The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.

21 January 2018

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ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions

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Enhanced morphine analgesia in mice lacking beta-arrestin 2

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Chronic obstructive pulmonary disease

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Phosphodiesterases: the journey towards therapeutics

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Identifiers

DOI

10.1074/JBC.M303772200

1 reference

22 September 2017

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