An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics (Q24321738)

1

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Wei Wong

2

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Jerome Schaack

3

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John D Scott

4

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Dermot M F Cooper

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

5

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language of work or name

English

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publication date

17 May 2006

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published in

The EMBO Journal

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volume

25

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issue

10

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page(s)

2051-61

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cites work

1 reference

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Protein kinase A regulates AKAP250 (gravin) scaffold binding to the beta2-adrenergic receptor

19 March 2017

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Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel

19 March 2017

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mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

19 March 2017

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Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1

19 March 2017

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Gravin-mediated formation of signaling complexes in beta 2-adrenergic receptor desensitization and resensitization

19 March 2017

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Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex

19 March 2017

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The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.

19 March 2017

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A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events

19 March 2017

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Voltage-dependent potentiation of L-type Ca2+ channels in skeletal muscle cells requires anchored cAMP-dependent protein kinase

19 March 2017

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Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain

19 March 2017

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AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation

19 March 2017

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Role for A kinase-anchoring proteins (AKAPS) in glutamate receptor trafficking and long term synaptic depression

19 March 2017

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Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels

19 March 2017

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The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization

19 March 2017

1 reference

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Simultaneous measurements of intracellular cAMP and L-type Ca2+ current in single frog ventricular myocytes

19 March 2017

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Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin

19 March 2017

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cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits

19 March 2017

1 reference

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Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein

19 March 2017

1 reference

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Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation

19 March 2017

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Regulation of adenylyl cyclase by protein kinase A

19 March 2017

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Association of protein kinase A and protein phosphatase 2B with a common anchoring protein

19 March 2017

1 reference

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beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi

19 March 2017

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Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins

19 March 2017

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Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area

19 March 2017

1 reference

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AKAP signalling complexes: focal points in space and time

19 March 2017

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Cyclic nucleotide-gated ion channels

7 April 2017

1 reference

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Prostanoid receptors: structures, properties, and functions

7 April 2017

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7 April 2017

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Ca2+ stimulation of adenylyl cyclase generates dynamic oscillations in cyclic AMP.

29 November 2018

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Distinct enzyme combinations in AKAP signalling complexes permit functional diversity

27 September 2017

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RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

27 September 2017

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Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract

27 September 2017

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Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes

27 September 2017

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Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium.

27 September 2017

1 reference

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AKAP (A-kinase anchoring protein) domains: beads of structure-function on the necklace of G-protein signalling

27 September 2017

1 reference

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Novel single chain cAMP sensors for receptor-induced signal propagation.

27 September 2017

1 reference

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Localized effects of cAMP mediated by distinct routes of protein kinase A.

27 September 2017

1 reference

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AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes

27 September 2017

1 reference

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Imaging kinase--AKAP79--phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462982

Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462982

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

27 September 2017

1 reference

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Compartmentalisation of cAMP and Ca(2+) signals

27 September 2017

1 reference

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A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell

27 September 2017

1 reference

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In vivo assessment of local phosphodiesterase activity using tailored cyclic nucleotide-gated channels as cAMP sensors

27 September 2017

1 reference

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Cyclic nucleotide-gated channels colocalize with adenylyl cyclase in regions of restricted cAMP diffusion

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462982

Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in Galphas stimulation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462982

cAMP compartmentation is responsible for a local activation of cardiac Ca2+ channels by beta-adrenergic agonists

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462982

A kinase anchor protein 75 targets regulatory (RII) subunits of cAMP-dependent protein kinase II to the cortical actin cytoskeleton in non-neuronal cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462982

Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462982

Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility

27 September 2017

1 reference

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Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons.

30 May 2018

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Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels.

30 May 2018

1 reference

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Cyclic nucleotide research -- still expanding after half a century

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462982

Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes

29 November 2018

1 reference

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Identification of a region of the C-terminal domain involved in short-term desensitization of the prostaglandin EP4 receptor

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462982

Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462982

Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16642035

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16642035

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.EMBOJ.7601113

1 reference

131020

131020

1 reference

1 reference

1 reference