Presenilin regulates insulin signaling via a gamma-secretase-independent mechanism (Q41953121)

14 October 2017

Presenilin regulates insulin signaling via a gamma-secretase-independent mechanism (English)

1 reference

14 October 2017

Masato Maesako

1

1 reference

14 October 2017

Kengo Uemura

2

1 reference

14 October 2017

Akira Kuzuya

3

1 reference

14 October 2017

Kazuki Sasaki

4

1 reference

14 October 2017

Megumi Asada

5

1 reference

14 October 2017

Kiwamu Watanabe

6

1 reference

14 October 2017

Koichi Ando

7

1 reference

14 October 2017

Masakazu Kubota

8

1 reference

14 October 2017

Takeshi Kihara

9

1 reference

14 October 2017

Ayae Kinoshita

10

1 reference

14 October 2017

language of work or name

English

0 references

publication date

26 May 2011

1 reference

Journal of Biological Chemistry

14 October 2017

1 reference

14 October 2017

286

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14 October 2017

28

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14 October 2017

25309-25316

1 reference

describes a project that uses

14 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3137102/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis

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Effect of glycogen synthase kinase 3 β-mediated presenilin 1 phosphorylation on amyloid β production is negatively regulated by insulin receptor cleavage

5 June 2018

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Insulin regulates Presenilin 1 localization via PI3K/Akt signaling

5 June 2018

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Novel research horizons for presenilins and γ-secretases in cell biology and disease

5 June 2018

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Role of presenilins in neuronal calcium homeostasis

5 June 2018

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PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity

5 June 2018

1 reference

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Presenilins are essential for regulating neurotransmitter release

5 June 2018

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Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity

5 June 2018

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Presenilin: RIP and beyond

5 June 2018

1 reference

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Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway.

5 June 2018

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Genetic and pharmacological inhibition of Rho-associated kinase II enhances adipogenesis.

5 June 2018

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Protein kinase Cepsilon interacts with Stat3 and regulates its activation that is essential for the development of skin cancer

5 June 2018

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Generation of intracellular domain of insulin receptor tyrosine kinase by gamma-secretase.

5 June 2018

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Adipocyte differentiation from the inside out

5 June 2018

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Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

5 June 2018

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Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors

5 June 2018

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Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling.

5 June 2018

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Role for neuronal insulin resistance in neurodegenerative diseases

5 June 2018

1 reference

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Gamma-secretase activity is not involved in presenilin-mediated regulation of beta-catenin.

5 June 2018

1 reference

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

5 June 2018

1 reference

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

5 June 2018

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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

5 June 2018

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Insulin signalling and the regulation of glucose and lipid metabolism

5 June 2018

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Role of insulin and insulin receptor in learning and memory

5 June 2018

1 reference

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Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

5 June 2018

1 reference

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

5 June 2018

1 reference

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Presenilin is required for activity and nuclear access of Notch in Drosophila

5 June 2018

1 reference

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Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT

5 June 2018

2 references

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5 June 2018

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Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

21 January 2018

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The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137102

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137102

beta-catenin is a target for the ubiquitin-proteasome pathway

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137102

Signalling downstream of activated mammalian Notch

5 June 2018

1 reference

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Cellular trafficking and processing of the insulin receptor

5 June 2018

1 reference

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

5 June 2018

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gamma-secretase inhibitor induces adipogenesis of adipose-derived stem cells by regulation of Notch and PPAR-gamma.

5 June 2018

1 reference

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Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137102

Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137102

Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137102

Insulin signaling in health and disease

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21622565

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M111.248922

1 reference

14 October 2017

1 reference

14 October 2017

1 reference