Identification of an Htm1 (EDEM)-dependent, Mns1-independent Endoplasmic Reticulum-associated Degradation (ERAD) pathway in Saccharomyces cerevisiae: application of a novel assay for glycoprotein ERAD. (Q41860491)

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scientific article published on 28 May 2010

Language	Label	Description	Also known as
English	Identification of an Htm1 (EDEM)-dependent, Mns1-independent Endoplasmic Reticulum-associated Degradation (ERAD) pathway in Saccharomyces cerevisiae: application of a novel assay for glycoprotein ERAD.	scientific article published on 28 May 2010

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scholarly article

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4 February 2020

Identification of an Htm1 (EDEM)-dependent, Mns1-independent Endoplasmic Reticulum-associated Degradation (ERAD) pathway in Saccharomyces cerevisiae: application of a novel assay for glycoprotein ERAD (English)

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4 February 2020

endoplasmic reticulum

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Saccharomyces cerevisiae

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based on heuristic

inferred from title

Hiroto Hirayama

3

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Akira Hosomi

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Kaori Tanabe

2

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Ikjin Kim

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Hai Rao

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Tadashi Suzuki

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28 May 2010

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Journal of Biological Chemistry

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285

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24324-24334

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4 February 2020

Free oligosaccharides to monitor glycoprotein endoplasmic reticulum-associated degradation in Saccharomyces cerevisiae

1 reference

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5 June 2018

Usa1 protein facilitates substrate ubiquitylation through two separate domains

1 reference

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Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans

1 reference

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5 June 2018

Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum

1 reference

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5 June 2018

Defining the glycan destruction signal for endoplasmic reticulum-associated degradation

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5 June 2018

One step at a time: endoplasmic reticulum-associated degradation

1 reference

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5 June 2018

Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum

1 reference

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5 June 2018

Protein quality control in the early secretory pathway

1 reference

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Dissecting the ER-associated degradation of a misfolded polytopic membrane protein

1 reference

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Derlin-1 and p97/valosin-containing protein mediate the endoplasmic reticulum-associated degradation of human V2 vasopressin receptors

1 reference

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5 June 2018

N-linked glycosylation does not impair proteasomal degradation but affects class I major histocompatibility complex presentation

1 reference

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5 June 2018

Cytoplasmic peptide:N-glycanase and catabolic pathway for free N-glycans in the cytosol

1 reference

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5 June 2018

Retrotranslocation of a viral A/B toxin from the yeast endoplasmic reticulum is independent of ubiquitination and ERAD.

1 reference

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5 June 2018

EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Sel1p/Ubx2p participates in a distinct Cdc48p-dependent endoplasmic reticulum-associated degradation pathway

1 reference

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5 June 2018

Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator

1 reference

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5 June 2018

Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol

1 reference

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5 June 2018

EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

The Png1-Rad23 complex regulates glycoprotein turnover

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Inositol deacylation by Bst1p is required for the quality control of glycosylphosphatidylinositol-anchored proteins

1 reference

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5 June 2018

Endoplasmic reticulum-associated degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Ubx2 links the Cdc48 complex to ER-associated protein degradation

1 reference

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5 June 2018

Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Yos9p detects and targets misfolded glycoproteins for ER-associated degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate

1 reference

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5 June 2018

Search and destroy: ER quality control and ER-associated protein degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

A genome-wide screen identifies Yos9p as essential for ER-associated degradation of glycoproteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

1 reference

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5 June 2018

A membrane protein required for dislocation of misfolded proteins from the ER

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Multiple interactions of rad23 suggest a mechanism for ubiquitylated substrate delivery important in proteolysis

1 reference

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5 June 2018

Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

1 reference

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5 June 2018

A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised

1 reference

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5 June 2018

YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins

1 reference

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5 June 2018

ER-golgi traffic is a prerequisite for efficient ER degradation.

1 reference

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5 June 2018

Rad23 promotes the targeting of proteolytic substrates to the proteasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Cytoplasmic peptide:N-glycanase (PNGase) in eukaryotic cells: occurrence, primary structure, and potential functions

1 reference

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5 June 2018

Systematic genetic analysis with ordered arrays of yeast deletion mutants

1 reference

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5 June 2018

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

1 reference

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5 June 2018

Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding

1 reference

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5 June 2018

A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation

1 reference

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5 June 2018

Identification of proteins that interact with mammalian peptide:N-glycanase and implicate this hydrolase in the proteasome-dependent pathway for protein degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Htm1p, a mannosidase-like protein, is involved in glycoprotein degradation in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation

1 reference

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5 June 2018

Rad23 provides a link between the Png1 deglycosylating enzyme and the 26 S proteasome in yeast.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Mnl1p, an alpha -mannosidase-like protein in yeast Saccharomyces cerevisiae, is required for endoplasmic reticulum-associated degradation of glycoproteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.

1 reference

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5 June 2018

Rapid and reliable protein extraction from yeast

1 reference

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5 June 2018

PNG1, a yeast gene encoding a highly conserved peptide:N-glycanase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Degradation of unassembled Vph1p reveals novel aspects of the yeast ER quality control system

1 reference

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5 June 2018

Eps1, a novel PDI-related protein involved in ER quality control in yeast

1 reference

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5 June 2018

Biochemical analysis of the Saccharomyces cerevisiae SEC18 gene product: implications for the molecular mechanism of membrane fusion

1 reference

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5 June 2018

Degradation of misfolded endoplasmic reticulum glycoproteins in Saccharomyces cerevisiae is determined by a specific oligosaccharide structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Role of Cue1p in ubiquitination and degradation at the ER surface

1 reference

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5 June 2018

Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

N-Glycosylation affects endoplasmic reticulum degradation of a mutated derivative of carboxypeptidase yscY in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Green fluorescent protein as a marker for gene expression and subcellular localization in budding yeast

1 reference

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5 June 2018

ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

5 June 2018

S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase

1 reference

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5 June 2018

Getting started with yeast

1 reference

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5 June 2018

Dual-gradient high-performance liquid chromatography for identification of cytosolic high-mannose-type free glycans

1 reference

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18 August 2018

HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation.

1 reference

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18 August 2018

Dislocation of an endoplasmic reticulum membrane glycoprotein involves the formation of partially dislocated ubiquitinated polypeptides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

18 August 2018

Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD.

1 reference

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18 August 2018

Glycopeptide export from the endoplasmic reticulum into cytosol is mediated by a mechanism distinct from that for export of misfolded glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915668

18 August 2018

Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/20511219

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of carbohydrate positioning in the recognition of mutated CPY for ER-associated degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20511219

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The N-terminal ricin propeptide influences the fate of ricin A-chain in tobacco protoplasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/20511219

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cytoplasmic peptide: N-glycanase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20511219

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20511219

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of endoplasmic reticulum (ER) quality control substrates requires transport between the ER and Golgi

1 reference

https://pubmed.ncbi.nlm.nih.gov/20511219

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.095919

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20511219%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20511219%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20511219%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

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