Downregulation of uPA, uPAR and MMP-9 using small, interfering, hairpin RNA (siRNA) inhibits glioma cell invasion, angiogenesis and tumor growth (Q41667528)

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scientific article published on May 2004

Language	Label	Description	Also known as
English	Downregulation of uPA, uPAR and MMP-9 using small, interfering, hairpin RNA (siRNA) inhibits glioma cell invasion, angiogenesis and tumor growth	scientific article published on May 2004

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scholarly article

1 reference

Europe PubMed Central

6 October 2017

Downregulation of uPA, uPAR and MMP-9 using small, interfering, hairpin RNA (siRNA) inhibits glioma cell invasion, angiogenesis and tumor growth (English)

1 reference

Europe PubMed Central

6 October 2017

6

object named as

Jasti S Rao

1 reference

Europe PubMed Central

6 October 2017

author name string

Christopher S Gondi

1

1 reference

Europe PubMed Central

6 October 2017

Sajani S Lakka

2

1 reference

Europe PubMed Central

6 October 2017

Dzung H Dinh

3

1 reference

Europe PubMed Central

6 October 2017

William C Olivero

4

1 reference

Europe PubMed Central

6 October 2017

Meena Gujrati

5

1 reference

Europe PubMed Central

6 October 2017

publication date

1 May 2004

1 reference

Europe PubMed Central

6 October 2017

Neuron Glia Biology

1 reference

Europe PubMed Central

6 October 2017

1

1 reference

Europe PubMed Central

6 October 2017

2

1 reference

Europe PubMed Central

6 October 2017

165-176

1 reference

Europe PubMed Central

6 October 2017

Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483066

6 June 2018

Expression of antisense uPAR and antisense uPA from a bicistronic adenoviral construct inhibits glioma cell invasion, tumor growth, and angiogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483066

6 June 2018

RNAi: gene-silencing in therapeutic intervention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483066

6 June 2018

Adenovirus-mediated expression of antisense MMP-9 in glioma cells inhibits tumor growth and invasion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483066

6 June 2018

Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor

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6 June 2018

PTEN suppresses hyaluronic acid-induced matrix metalloproteinase-9 expression in U87MG glioblastoma cells through focal adhesion kinase dephosphorylation.

1 reference

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Downregulation of MMP-9 in ERK-mutated stable transfectants inhibits glioma invasion in vitro

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New functions for the matrix metalloproteinases in cancer progression

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RNA interference: listening to the sound of silence

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Stable transfection of urokinase-type plasminogen activator antisense construct modulates invasion of human glioblastoma cells.

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Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

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Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades

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Localization of gelatinase-A and gelatinase-B mRNA and protein in human gliomas

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Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion

1 reference

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6 June 2018

MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis

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Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

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Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis

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3-Amidinophenylalanine-based inhibitors of urokinase

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Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer

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Gene therapy for gliomas: molecular targets, adenoviral vectors, and oncolytic adenoviruses

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Roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the signal transduction of basic fibroblast growth factor in endothelial cells during angiogenesis

1 reference

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6 June 2018

The role of the plasminogen activation system in cancer.

1 reference

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6 June 2018

Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas

1 reference

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6 June 2018

The urokinase receptor. A cell surface, regulated chemokine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483066

6 June 2018

Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483066

6 June 2018

The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483066

6 June 2018

Downstream targets of urokinase-type plasminogen-activator-mediated signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483066

6 June 2018

Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility

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6 June 2018

Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483066

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Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice

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6 June 2018

Inhibition of in vivo tumorigenicity and invasiveness of a human glioblastoma cell line transfected with antisense uPAR vectors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483066

6 June 2018

The urokinase-type plasminogen activator system in cancer metastasis: a review

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6 June 2018

Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation

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Extracellular matrix remodeling as a regulator of stromal-epithelial interactions during mammary gland development, involution and carcinogenesis.

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In vitro inhibition of human glioblastoma cell line invasiveness by antisense uPA receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483066

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Reduction in surface urokinase receptor forces malignant cells into a protracted state of dormancy

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Inhibition of matrix metalloproteinase 9 expression by a ribozyme blocks metastasis in a rat sarcoma model system.

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Expression of multiple CD44 isoforms in the apical ectodermal ridge of the embryonic mouse limb.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483066

6 June 2018

Urokinase antisense oligodeoxynucleotides as a novel therapeutic agent for malignant glioma: in vitro and in vivo studies of uptake, effects and toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483066

6 June 2018

Glioma invasion in the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483066

6 June 2018

Generation and characterization of urokinase receptor-deficient mice

1 reference

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Transfection of an invasive human astrocytoma cell line with a TIMP-1 cDNA: modulation of astrocytoma invasive potential.

1 reference

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6 June 2018

Prevention of metastasis by inhibition of the urokinase receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483066

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Expression and localization of urokinase-type plasminogen activator in human astrocytomas in vivo.

1 reference

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Up-regulation of urokinase and urokinase receptor genes in malignant astrocytoma

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Urokinase plasminogen activator is necessary but not sufficient for prostate cancer cell invasion.

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Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas

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Migratory patterns of lac-z transfected human glioma cells in the rat brain

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Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells

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Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor

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The urokinase receptor: involvement in cell surface proteolysis and cancer invasion

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Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas

1 reference

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VEGF-induced paracellular permeability in cultured endothelial cells involves urokinase and its receptor

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Germline transmission of RNAi in mice

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Modulation of invasive properties of human glioblastoma cells stably expressing amino-terminal fragment of urokinase-type plasminogen activator.

1 reference

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High-affinity urokinase-derived cyclic peptides inhibiting urokinase/urokinase receptor-interaction: effects on tumor growth and spread

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Active matrix metalloproteinase 9 expression is associated with primary glioblastoma subtype.

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Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo.

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1 reference

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1 reference

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Adenovirus-mediated delivery of antisense gene to urokinase-type plasminogen activator receptor suppresses glioma invasion and tumor growth.

1 reference

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Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice

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Expression and localization of 92 kDa type IV collagenase/gelatinase B (MMP-9) in human gliomas.

1 reference

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Elevated levels of M(r) 92,000 type IV collagenase in human brain tumors.

1 reference

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Expression and localization of urokinase-type plasminogen activator receptor in human gliomas.

1 reference

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Expression of tissue inhibitors of metalloproteinases: negative regulators of human glioblastoma invasion in vivo.

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based on heuristic

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Urokinase-type plasminogen activation in three human breast cancer cell lines correlates with their in vitro invasiveness

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804563

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of mammary tumor cell adhesion, migration, and invasion by the selective synthetic urokinase inhibitor B428

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804563

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological Activation of pro-HGF (Hepatocyte Growth Factor) by Urokinase Is Controlled by a Stoichiometric Reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804563

12 December 2020

based on heuristic

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Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice

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https://pubmed.ncbi.nlm.nih.gov/16804563

12 December 2020

based on heuristic

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Effects of synthetic urokinase inhibitors on local invasion and metastasis in a murine mammary tumor model

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804563

12 December 2020

based on heuristic

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Identifiers

10.1017/S1740925X04000237

1 reference

Europe PubMed Central

6 October 2017

1 reference

Europe PubMed Central

6 October 2017

1 reference

Europe PubMed Central

6 October 2017

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