Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance (Q41663538)

6 October 2017

Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance (English)

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6 October 2017

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Olefsky JM

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6 October 2017

Egawa K

1

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6 October 2017

Sharma PM

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6 October 2017

Nakashima N

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6 October 2017

Huang Y

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6 October 2017

Huver E

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6 October 2017

Boss GR

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6 October 2017

language of work or name

English

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publication date

1 May 1999

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Journal of Biological Chemistry

6 October 2017

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6 October 2017

274

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6 October 2017

14306-14314

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6 October 2017

20

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Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site

6 October 2017

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Requirement for phosphoinositide 3-kinase in insulin-stimulated GLUT4 translocation in 3T3-L1 adipocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Growth factor-induced stimulation of hexose transport in 3T3-L1 adipocytes: evidence that insulin-induced translocation of GLUT4 is independent of activation of MAP kinase.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Intracellular localization of phosphatidylinositide 3-kinase and insulin receptor substrate-1 in adipocytes: potential involvement of a membrane skeleton

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Insulin-mediated targeting of phosphatidylinositol 3-kinase to GLUT4-containing vesicles

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Overexpression of catalytic subunit p110alpha of phosphatidylinositol 3-kinase increases glucose transport activity with translocation of glucose transporters in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Adenovirus-mediated overexpression of IRS-1 interacting domains abolishes insulin-stimulated mitogenesis without affecting glucose transport in 3T3-L1 adipocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Activation of phosphatidylinositol 3-kinase by insulin

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: comparison of parental and Ras-overproducing NIH 3T3 fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

A novel technique for the study of Ras activity: electroporation of [alpha-32P]GTP.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Effect of the activation of phosphatidylinositol 3-kinase by a thiophosphotyrosine peptide on glucose transport in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Association of p21ras with phosphatidylinositol 3-kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

The activation of glycogen synthase by insulin switches from kinase inhibition to phosphatase activation during adipogenesis in 3T3-L1 cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

ATP citrate-lyase and glycogen synthase kinase-3 beta in 3T3-L1 cells during differentiation into adipocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

New insights into the role and mechanism of glycogen synthase activation by insulin

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.20.14306

21 January 2018

Identifiers

DOI

10.1074/JBC.274.20.14306

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6 October 2017

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