Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation (Q34254516)

31 July 2017

title

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation (English)

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31 July 2017

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5

L T Williams

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31 July 2017

Q P Weng

1

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31 July 2017

K Andrabi

2

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31 July 2017

A Klippel

3

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31 July 2017

M T Kozlowski

4

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31 July 2017

J Avruch

6

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31 July 2017

publication date

1 June 1995

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Proceedings of the National Academy of Sciences of the United States of America

31 July 2017

language of work or name

English

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published in

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31 July 2017

volume

92

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31 July 2017

issue

12

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31 July 2017

page(s)

5744-5748

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A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo

31 July 2017

cites work

1 reference

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6 July 2018

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A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

6 July 2018

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PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

6 July 2018

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6 July 2018

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The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity

6 July 2018

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Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta

6 July 2018

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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

6 July 2018

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PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

6 July 2018

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Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

6 July 2018

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Multiple independent inputs are required for activation of the p70 S6 kinase

6 July 2018

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Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

6 July 2018

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Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

6 July 2018

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6 July 2018

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Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product

6 July 2018

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Rapid and efficient site-specific mutagenesis without phenotypic selection

6 July 2018

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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

6 July 2018

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Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

6 July 2018

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Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

6 July 2018

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Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase

6 July 2018

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Insulin activates a 70-kDa S6 kinase through serine/threonine-specific phosphorylation of the enzyme polypeptide

6 July 2018

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Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini

6 July 2018

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Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

6 July 2018

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cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

6 July 2018

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An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase

6 July 2018

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Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

6 July 2018

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Purification and characterisation of the insulin-stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II.

6 July 2018

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Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs

6 July 2018

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Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit

6 July 2018

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ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

6 July 2018

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Regulation of an epitope-tagged recombinant Rsk-1 S6 kinase by phorbol ester and erk/MAP kinase

6 July 2018

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Insulin-activated protein kinases phosphorylate a pseudosubstrate synthetic peptide inhibitor of the p70 S6 kinase

28 October 2018

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12 December 2020

p70s6k function is essential for G1 progression

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12 December 2020

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin

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12 December 2020

Hot lips and phosphorylation of protein kinases

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12 December 2020

Identifiers

DOI

10.1073/PNAS.92.12.5744

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31 July 2017

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31 July 2017

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