The dual structural roles of the membrane distal region of the α-integrin cytoplasmic tail during integrin inside-out activation (Q41271593)

30 June 2019

title

The dual structural roles of the membrane distal region of the α-integrin cytoplasmic tail during integrin inside-out activation (English)

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30 June 2019

author name string

Jiafu Liu

1

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30 June 2019

Zhengli Wang

2

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30 June 2019

Aye Myat Myat Thinn

3

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30 June 2019

Yan-Qing Ma

4

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30 June 2019

Jieqing Zhu

5

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30 June 2019

language of work or name

English

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publication date

6 March 2015

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30 June 2019

published in

Journal of Cell Science

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30 June 2019

volume

128

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30 June 2019

issue

9

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30 June 2019

page(s)

1718-1731

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30 June 2019

Quantitative changes in integrin and focal adhesion signaling regulate myoblast cell cycle withdrawal

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A structural basis for integrin activation by the cytoplasmic tail of the alpha IIb-subunit

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How proteins adapt to a membrane-water interface

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A membrane-distal segment of the integrin alpha IIb cytoplasmic domain regulates integrin activation.

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C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1

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Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

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Integrins: bidirectional, allosteric signaling machines

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Differential regulation of cell adhesive functions by integrin alpha subunit cytoplasmic tails in vivo

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RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

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Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.

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Antibody against the Leu-CAM beta-chain (CD18) promotes both LFA-1- and CR3-dependent adhesion events

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Monoclonal antibodies as probes of integrin priming and activation.

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Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

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Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains

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Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state

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Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.

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CIB1 is an endogenous inhibitor of agonist-induced integrin alphaIIbbeta3 activation

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Regulation of Integrin αIIbβ3Activation by Distinct Regions of Its Cytoplasmic Tails†

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Genetic analysis of beta1 integrin "activation motifs" in mice

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Activation of leukocyte beta2 integrins by conversion from bent to extended conformations

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Further characterization of the loop structure of platelet glycoprotein IIIa: partial mapping of functionally significant glycoprotein IIIa epitopes

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Structural basis of integrin activation by talin

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Tests of the extension and deadbolt models of integrin activation

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A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia

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The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate beta1 and beta3 integrins

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Kindlin-3 is essential for integrin activation and platelet aggregation

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Kindlin-2 (Mig-2): a co-activator of beta3 integrins.

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Functional analysis of the cytoplasmic domain of the integrin {alpha}1 subunit in endothelial cells

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Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates alpha(4) integrins

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Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.

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A palmitoylated peptide, derived from the acidic carboxyl-terminal segment of the integrin alphaIIb cytoplasmic domain, inhibits platelet activation

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12 December 2020

Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex

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Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

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Structural Determinants of Integrin Binding to the Talin Rod

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Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation

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A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

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Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells

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Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

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Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects

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The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling

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The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3.

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The tail of integrins, talin, and kindlins

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Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb

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The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.

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Structure of an integrin IIb 3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation

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Anti-integrin monoclonal antibodies

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Recreation of the terminal events in physiological integrin activation

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Consensus motif for integrin transmembrane helix association

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12 December 2020

The final steps of integrin activation: the end game

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12 December 2020

Protein interactions with the platelet integrin alpha(IIb) regulatory motif

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12 December 2020

Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2.

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12 December 2020

NMR analysis of the IIb 3 cytoplasmic interaction suggests a mechanism for integrin regulation

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12 December 2020

The tail of integrin activation

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12 December 2020

Heterozygous ITGA2B R995W mutation inducing constitutive activation of the αIIbβ3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia

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12 December 2020

Regulation of integrin activation

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12 December 2020

Multiscale simulations suggest a mechanism for integrin inside-out activation

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12 December 2020

Molecular mechanism of inside-out integrin regulation

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12 December 2020

Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopy

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12 December 2020

Talin and signaling through integrins

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12 December 2020

Mechanisms of integrin activation and trafficking

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12 December 2020

Regulation of integrin affinity on cell surfaces

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12 December 2020

Integrin inside-out signaling and the immunological synapse

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12 December 2020

Basic amino-acid side chains regulate transmembrane integrin signalling

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12 December 2020

Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment.

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12 December 2020

Structure-Guided Design of a High-Affinity Platelet Integrin IIb 3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS

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12 December 2020

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

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12 December 2020

Integrin αIIbβ3 inside-out activation: an in situ conformational analysis reveals a new mechanism

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12 December 2020

Talin activates integrins by altering the topology of the β transmembrane domain

1 reference

12 December 2020

Spatial coordination of kindlin-2 with talin head domain in interaction with integrin β cytoplasmic tails

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12 December 2020

A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion

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12 December 2020

Negative regulators of integrin activity

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12 December 2020

Integrin inactivators: balancing cellular functions in vitro and in vivo

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12 December 2020

Complete integrin headpiece opening in eight steps

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12 December 2020

Talins and kindlins: partners in integrin-mediated adhesion.

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12 December 2020

Mechanisms of talin-dependent integrin signaling and crosstalk

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12 December 2020

Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation

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12 December 2020

Modulation of integrin activation and signaling by α1/α1'-helix unbending at the junction

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12 December 2020

Conformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helices

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12 December 2020

The mechanism of kindlin-mediated activation of integrin αIIbβ3.

1 reference

12 December 2020

Palmitoylated peptide, being derived from the carboxyl-terminal sequence of the integrin αIIb cytoplasmic domain, inhibits talin binding to αIIbβ₃

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12 December 2020

Integrin cytoplasmic tail interactions

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12 December 2020

Talin-driven inside-out activation mechanism of platelet αIIbβ3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations

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12 December 2020

Regulated splicing of the α6 integrin cytoplasmic domain determines the fate of breast cancer stem cells

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12 December 2020

Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits

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12 December 2020

Integrin αII b tail distal of GFFKR participates in inside-out αII b β3 activation

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12 December 2020

Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3

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12 December 2020

A beta turn in the cytoplasmic tail of the integrin alpha v subunit influences conformation and ligand binding of alpha v beta 3.

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12 December 2020

Integrin cytoplasmic domains mediate inside-out signal transduction

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12 December 2020

The alpha 6A beta 1 and alpha 6B beta 1 integrin variants signal differences in the tyrosine phosphorylation of paxillin and other proteins

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12 December 2020

Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrin

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12 December 2020

The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity.

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12 December 2020

Integrin alpha 2 cytoplasmic domain deletion effects: loss of adhesive activity parallels ligand-independent recruitment into focal adhesions

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12 December 2020

Minimum alpha chain cytoplasmic tail sequence needed to support integrin-mediated adhesion.

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12 December 2020

Regulation of alpha 6 beta 1 integrin laminin receptor function by the cytoplasmic domain of the alpha 6 subunit

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12 December 2020

Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions.

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12 December 2020

Role of the alpha subunit cytoplasmic domain in regulation of adhesive activity mediated by the integrin VLA-2.

1 reference

12 December 2020

Breaking the integrin hinge. A defined structural constraint regulates integrin signaling

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12 December 2020

Direct binding of the platelet integrin alphaIIbbeta3 (GPIIb-IIIa) to talin. Evidence that interaction is mediated through the cytoplasmic domains of both alphaIIb and beta3

1 reference

12 December 2020

The alpha subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte function-associated antigen-1

1 reference

12 December 2020

Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding

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12 December 2020

R to Q amino acid substitution in the GFFKR sequence of the cytoplasmic domain of the integrin IIb subunit in a patient with a Glanzmann's thrombasthenia-like syndrome

1 reference

12 December 2020

Identifiers

DOI

10.1242/JCS.160663

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30 June 2019

PMCID

6518327

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30 June 2019

PubMed ID

25749862

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30 June 2019