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BCL2 associated X, apoptosis regulator (Q408476)

From Wikidata
mammalian protein found in Homo sapiens
  • BAX
  • bcl-2-like protein 4
  • bcl2-L-4
  • Baxdelta2G9
  • Baxdelta2G9omega
  • BCL2 associated X protein
  • BCL2-associated X protein omega
  • Baxdelta2omega
  • apoptosis regulator BAX
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    English
    BCL2 associated X, apoptosis regulator
    mammalian protein found in Homo sapiens
    • BAX
    • bcl-2-like protein 4
    • bcl2-L-4
    • Baxdelta2G9
    • Baxdelta2G9omega
    • BCL2 associated X protein
    • BCL2-associated X protein omega
    • Baxdelta2omega
    • apoptosis regulator BAX

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    58 references
    retrieved
    8 April 2019
    stated in
    Humanin peptide suppresses apoptosis by interfering with Bax activation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q07812
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RACK1 promotes Bax oligomerization and dissociates the interaction of Bax and Bcl-XL
    GOA
    curator
    UniProt
    UniProt protein ID
    Q07812
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q07812
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q07812
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    IAN family critically regulates survival and development of T lymphocytes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Humanin peptide suppresses apoptosis by interfering with Bax activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mcl-1(128-350) fragment induces apoptosis through direct interaction with Bax
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human nuclear clusterin mediates apoptosis by interacting with Bcl‐XL through C‐terminal coiled coil domain
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The DNA-binding domain mediates both nuclear and cytosolic functions of p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human Bop is a novel BH3-only member of the Bcl-2 protein family
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BAX activation is initiated at a novel interaction site
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    An interconnected hierarchical model of cell death regulation by the BCL-2 family
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    UV irradiation resistance‐associated gene suppresses apoptosis by interfering with BAX activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bcl-XL inhibits membrane permeabilization by competing with Bax.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c release
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SH3GLB, a new endophilin-related protein family featuring an SH3 domain
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Clusterin inhibits apoptosis by interacting with activated Bax
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma
    GOA
    curator
    AgBase
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    identical protein binding
    determination method or standard
    IPI
    14 references
    retrieved
    8 April 2019
    stated in
    The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A short Nur77-derived peptide converts Bcl-2 from a protector to a killer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bcl-XL inhibits membrane permeabilization by competing with Bax.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Viral apoptosis is induced by IRF-3-mediated activation of Bax
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Clusterin inhibits apoptosis by interacting with activated Bax
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IPI
    cell component
    cytosol
    determination method or standard
    IDA
    IEA
    TAS
    8 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways
    GOA
    curator
    UniProt
    UniProt protein ID
    Q07812
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    BOK and NOXA are essential mediators of p53-dependent apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q07812
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The expression of a new variant of the pro-apoptotic molecule Bax, Baxpsi, is correlated with an increased survival of glioblastoma multiforme patients
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma
    GOA
    curator
    AgBase
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IDA
    mitochondrion
    determination method or standard
    IDA
    IEA
    8 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    Q07812
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways
    GOA
    curator
    UniProt
    UniProt protein ID
    Q07812
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    BOK and NOXA are essential mediators of p53-dependent apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q07812
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The expression of a new variant of the pro-apoptotic molecule Bax, Baxpsi, is correlated with an increased survival of glioblastoma multiforme patients
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    MAP-1 is a mitochondrial effector of Bax.
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IDA
    biological process
    positive regulation of apoptotic process
    determination method or standard
    IBA
    IDA
    IEA
    IMP
    6 references
    retrieved
    8 April 2019
    stated in
    Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    GOA
    curator
    UniProt
    UniProt protein ID
    Q07812
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Identification of novel regulators of apoptosis using a high-throughput cell-based screen.
    GOA
    curator
    UniProt
    UniProt protein ID
    Q07812
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Cell-based screening and validation of human novel genes associated with cell viability
    GOA
    curator
    UniProt
    UniProt protein ID
    Q07812
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
    determination method or standard
    IBA
    Gene Atlas image
    PBB GE BAX 208478 s at fs.png
    732 × 530; 11 KB
    0 references

    Identifiers

    MeSH descriptor ID
    D051028
    subject named as
    bcl-2-Associated X Protein
    0 references
    PDB structure ID
     
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q408476&oldid=2396443592"