Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis (Q24306784)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14752512%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

title

Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis (English)

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17 November 2019

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GOA release 2020-03-11

negative regulation of apoptotic process

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GOA release 2020-03-11

author

Yingwei Mao

1

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17 November 2019

author name string

J-P Liu

2

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17 November 2019

H Xiang

3

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17 November 2019

D W-C Li

4

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17 November 2019

language of work or name

English

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publication date

1 May 2004

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Cell Death & Differentiation

17 November 2019

published in

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17 November 2019

volume

11

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17 November 2019

page(s)

512-526

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17 November 2019

issue

5

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Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals

17 November 2019

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Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor

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BCL-2 family members and the mitochondria in apoptosis

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Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

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Movement of Bax from the cytosol to mitochondria during apoptosis

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Regulated targeting of BAX to mitochondria.

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Conformation of the Bax C-terminus regulates subcellular location and cell death

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Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing

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Structure of Bax: coregulation of dimer formation and intracellular localization

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p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons

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Bax directly induces release of cytochrome c from isolated mitochondria

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Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions

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Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore

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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

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A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells

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Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis

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Bcl-xS and Bax induce different apoptotic pathways in PC12 cells

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7 January 2021

Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death.

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7 January 2021

Binding of the stress protein alpha B-crystallin to cardiac myofibrils correlates with the degree of myocardial damage during ischemia/reperfusion in vivo

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7 January 2021

alpha B-crystallin gene induction and phosphorylation by MKK6-activated p38. A potential role for alpha B-crystallin as a target of the p38 branch of the cardiac stress response

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7 January 2021

Differential protective activity of alpha A- and alphaB-crystallin in lens epithelial cells.

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7 January 2021

Caspase-3 is actively involved in okadaic acid-induced lens epithelial cell apoptosis

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7 January 2021

Human bcl-2 gene attenuates the ability of rabbit lens epithelial cells against H2O2-induced apoptosis through down-regulation of the alpha B-crystallin gene

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7 January 2021

The small heat shock protein alpha B-crystallin negatively regulates cytochrome c- and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation

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7 January 2021

Hsp27 negatively regulates cell death by interacting with cytochrome c.

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7 January 2021

HSP27 inhibits cytochrome c-dependent activation of procaspase-9.

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7 January 2021

Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3.

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7 January 2021

The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells.

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Protection of neuronal cells from apoptosis by Hsp27 delivered with a herpes simplex virus-based vector

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Hsp27 as a negative regulator of cytochrome C release

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Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

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Four small Drosophila heat shock proteins are related to each other and to mammalian alpha-crystallin

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Alpha-crystallin can function as a molecular chaperone

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Alpha-crystallin, a molecular chaperone, forms a stable complex with carbonic anhydrase upon heat denaturation

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7 January 2021

Characterization of the alpha-gamma and alpha-beta complex: evidence for an in vivo functional role of alpha-crystallin as a molecular chaperone.

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7 January 2021

Conformational and functional differences between recombinant human lens alphaA- and alphaB-crystallin

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7 January 2021

Alpha-crystallin/small heat shock protein has autokinase activity

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7 January 2021

Conversion from oligomers to tetramers enhances autophosphorylation by lens alpha A-crystallin. Specificity between alpha A- and alpha B-crystallin subunits.

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7 January 2021

Alpha B-crystallin expression in mouse NIH 3T3 fibroblasts: glucocorticoid responsiveness and involvement in thermal protection

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7 January 2021

Hypertonic stress induces alpha B-crystallin expression

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7 January 2021

The R116C mutation in alpha A-crystallin diminishes its protective ability against stress-induced lens epithelial cell apoptosis

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7 January 2021

The small heat shock protein alpha B-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activation

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7 January 2021

ARPE-19, a human retinal pigment epithelial cell line with differentiated properties

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7 January 2021

Properties of a clonal muscle cell line from rat heart

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7 January 2021

Autosomal dominant congenital cataract associated with a missense mutation in the human alpha crystallin gene CRYAA

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7 January 2021

A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy

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7 January 2021

Mutation of R116C results in highly oligomerized alpha A-crystallin with modified structure and defective chaperone-like function

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7 January 2021

Mutation R120G in alphaB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function

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7 January 2021

Regulation of cell death: the calcium-apoptosis link

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7 January 2021

Apoptosis by death factor

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7 January 2021

FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis

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7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

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7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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7 January 2021

Mitochondria and apoptosis

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Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

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7 January 2021

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

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7 January 2021

Staurosporine-induced neuronal death: multiple mechanisms and methodological implications

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7 January 2021

Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells.

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7 January 2021

Defective Bax activation in Hodgkin B-cell lines confers resistance to staurosporine-induced apoptosis

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7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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7 January 2021

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

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7 January 2021

A role for mitochondrial Bak in apoptotic response to anticancer drugs

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7 January 2021

bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells; however overexpression of bcl-2 does not protect against bak-mediated apoptosis

1 reference

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7 January 2021

Apoptosis in gastric epithelial cells is induced by Helicobacter pylori and accompanied by increased expression of BAK.

1 reference

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7 January 2021

Human lens epithelial cell line

1 reference

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7 January 2021

Okadaic acid-induced lens epithelial cell apoptosis requires inhibition of phosphatase-1 and is associated with induction of gene expression including p53 and bax.

1 reference

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7 January 2021

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

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7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401384

2 references

Consolidated OpenCitations Corpus – April 2017

2618863

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14752512%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

17 November 2019

1050311064

0 references

2618863

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

2618863

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14752512%20AND%20SRC:MED&resulttype=core&format=json