Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine. (Q40816316)

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6 November 2019

title

Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine (English)

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6 November 2019

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8

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6 November 2019

author name string

D Curman

1

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6 November 2019

B Cinel

2

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D E Williams

3

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N Rundle

4

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W D Block

5

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A A Goodarzi

6

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J R Hutchins

7

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B B Zhou

9

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S P Lees-Miller

10

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R J Andersen

11

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M Roberge

12

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language of work or name

English

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publication date

7 March 2001

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Journal of Biological Chemistry

6 November 2019

published in

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volume

276

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issue

21

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6 November 2019

page(s)

17914-17919

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Sensing and responding to DNA damage.

6 November 2019

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Checkpoints controlling mitosis

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The DNA damage response: putting checkpoints in perspective

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Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase

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Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.

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Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

21 January 2018

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Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

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A single ataxia telangiectasia gene with a product similar to PI-3 kinase

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

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Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

21 January 2018

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

21 January 2018

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A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

21 January 2018

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Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

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Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import

21 January 2018

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Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site

21 January 2018

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DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding

21 January 2018

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Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.

21 January 2018

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

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14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

21 January 2018

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Checkpoint pathways come of age.

21 January 2018

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Effects of caffeine on radiation-induced phenomena associated with cell-cycle traverse of mammalian cells

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The effect of caffeine on X-ray-induced mitotic delay in normal human and ataxia-telangiectasia fibroblasts

21 January 2018

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2-Aminopurine overrides multiple cell cycle checkpoints in BHK cells

21 January 2018

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UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

21 January 2018

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UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line

21 January 2018

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ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

21 January 2018

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Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

21 January 2018

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The topoisomerase II inhibitor VM-26 induces marked changes in histone H1 kinase activity, histones H1 and H3 phosphorylation, and chromosome condensation in G2 phase and mitotic BHK cells

21 January 2018

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The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner

21 January 2018

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Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent

21 January 2018

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Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

21 January 2018

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21 January 2018

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Identifiers

DOI

10.1074/JBC.M100728200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11279124%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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