Mutant K-ras enhances apoptosis in embryonic stem cells in combination with DNA damage and is associated with increased levels of p19(ARF). (Q40804654)

23 September 2017

Mutant K-ras enhances apoptosis in embryonic stem cells in combination with DNA damage and is associated with increased levels of p19(ARF). (English)

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23 September 2017

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Brooks DG

1

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23 September 2017

James RM

2

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23 September 2017

Patek CE

3

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23 September 2017

Williamson J

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23 September 2017

Arends MJ

5

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23 September 2017

language of work or name

English

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publication date

1 April 2001

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23 September 2017

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23 September 2017

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23 September 2017

2144-2152

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23 September 2017

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204309

23 September 2017

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases

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Splicing into senescence: the curious case of p16 and p19ARF.

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K-ras is an essential gene in the mouse with partial functional overlap with N-ras

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

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The ras oncogene-mediated sensitization of human cells to topoisomerase II inhibitor-induced apoptosis.

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Direct control of the Forkhead transcription factor AFX by protein kinase B

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Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas.

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

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P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells

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7 January 2021

Farnesyltransferase inhibitors: targeting the molecular basis of cancer

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7 January 2021

Ras signaling in tumor necrosis factor-induced apoptosis.

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7 January 2021

Endogenous c-N-Ras provides a steady-state anti-apoptotic signal

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204309

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Dimensions Publication ID

23 September 2017

1046915652

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Fatcat ID

release_mjgt3snsbzekrnr2jm7ibifqqe

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Fatcat

https://api.fatcat.wiki/v0/release/mjgt3snsbzekrnr2jm7ibifqqe

24 November 2022

mapped directly with Wikidata item

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