Peroxynitrite inactivates the human dopamine transporter by modification of cysteine 342: potential mechanism of neurotoxicity in dopamine neurons. (Q40728188)

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English	Peroxynitrite inactivates the human dopamine transporter by modification of cysteine 342: potential mechanism of neurotoxicity in dopamine neurons.	scientific article

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9 November 2019

Peroxynitrite inactivates the human dopamine transporter by modification of cysteine 342: potential mechanism of neurotoxicity in dopamine neurons (English)

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9 November 2019

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toxic encephalopathy

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Samuel U Park

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Jasmine V Ferrer

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Jonathan A Javitch

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Donald M Kuhn

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1 June 2002

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9 November 2019

Journal of Neuroscience

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4399-4405

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9 November 2019

Methamphetamine decreases mouse striatal dopamine transporter activity: roles of hyperthermia and dopamine

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12 December 2020

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Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

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Peroxynitrite-mediated oxidative protein modifications

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https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

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Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress.

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Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment

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12 December 2020

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Nitric oxide, mitochondria and neurological disease

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What we can learn from the effects of thiol reagents on transport proteins

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Peroxynitrite plays a role in methamphetamine-induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper-zinc superoxide dismutase

1 reference

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12 December 2020

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[(123)I]beta-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's disease and multiple system atrophy

1 reference

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12 December 2020

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Involvement of oxygen-based radicals in methamphetamine-induced neurotoxicity: evidence from the use of CuZnSOD transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

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Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

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https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

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Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

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Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

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Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

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Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

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Macrophage scavenger receptor confers an adherent phenotype to cells in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

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Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

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Probing structure of neurotransmitter transporters by substituted-cysteine accessibility method

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

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Methamphetamine generates peroxynitrite and produces dopaminergic neurotoxicity in mice: protective effects of peroxynitrite decomposition catalyst

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

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Methamphetamine-induced rapid and reversible reduction in the activities of tryptophan hydroxylase and dopamine transporters: oxidative consequences?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

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Protein nitration in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

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Oxidative chemistry of peroxynitrite

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

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Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

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Methamphetamine-induced rapid and reversible changes in dopamine transporter function: an in vitro model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[11C]RTI-32 PET studies of the dopamine transporter in early dopa-naive Parkinson's disease: implications for the symptomatic threshold.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of nitric oxide in methamphetamine neurotoxicity: protection by 7-nitroindazole, an inhibitor of neuronal nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

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inferred from PubMed ID database lookup

Oxygen radicals diminish dopamine transporter function in rat striatum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid and reversible effects of methamphetamine on dopamine transporters

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-4-Methylenedioxymethamphetamine-induced acute changes in dopamine transporter function

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

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Severe depletion of cocaine recognition sites associated with the dopamine transporter in Parkinson's-diseased striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

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[35] Assessment of peroxynitrite scavengers in Vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid and differential losses of in vivo dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) radioligand binding in MPTP-treated mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport-dependent accessibility of a cytoplasmic loop cysteine in the human dopamine transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and reversible change in dopamine transporters induced by methamphetamine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

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Inhibition of peroxynitrite-mediated oxidation of dopamine by flavonoid and phenolic antioxidants and their structural relationships

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of peroxynitrite-mediated tyrosine nitration by catechin polyphenols

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

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Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

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Kinetics of peroxynitrite reaction with amino acids and human serum albumin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nature of methamphetamine-induced rapid and reversible changes in dopamine transporters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and functional characterization of a cocaine-sensitive dopamine transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen radicals differentially affect Na+/Cl(-)-dependent transporters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of methamphetamine on Na(+)/Cl(-)-dependent transporters

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective labeling of neurotransmitter transporters at the cell surface.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anatomic and biochemical correlates of the dopamine transporter ligand 11C-PE2I in normal and parkinsonian primates: comparison with 6-[18F]fluoro-L-dopa

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[123I]beta-CIT SPECT imaging assessment of the rate of Parkinson's disease progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of MPTP toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurochemical findings in the MPTP model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection and quantitation of nitrotyrosine residues in proteins: in vivo marker of peroxynitrite

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoprecipitation of nitrotyrosine-containing proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methamphetamine-induced alterations in dopamine transporter function

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of neuronal oxidative damage in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging increases the susceptiblity to methamphetamine-induced dopaminergic neurotoxicity in rats: correlation with peroxynitrite production and hyperthermia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular physiology and regulation of catecholamine transporters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dopamine transporter: a crucial component regulating dopamine transmission.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased nitrotyrosine immunoreactivity in substantia nigra neurons in MPTP treated baboons is blocked by inhibition of neuronal nitric oxide synthase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methamphetamine-induced dopaminergic neurotoxicity: role of peroxynitrite and neuroprotective role of antioxidants and peroxynitrite decomposition catalysts

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methamphetamine- and 1-methyl-4-phenyl- 1,2,3, 6-tetrahydropyridine-induced dopaminergic neurotoxicity in inducible nitric oxide synthase-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and function of the dopamine transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12040046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-11-04399.2002

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9 November 2019

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9 November 2019

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9 November 2019

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