Structure and function of the dopamine transporter (Q34061069)

30 July 2017

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title

Structure and function of the dopamine transporter (English)

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30 July 2017

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Chen N

1

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PubMed ID

11033338

30 July 2017

Reith ME

series ordinal

2

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PubMed ID

11033338

30 July 2017

language of work or name

English

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publication date

1 September 2000

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European Journal of Pharmacology

30 July 2017

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30 July 2017

405

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30 July 2017

329-339

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30 July 2017

1-3

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Neurotransmitter transporters as molecular targets for addictive drugs.

30 July 2017

1 reference

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Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter.

7 January 2021

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Which form of dopamine is the substrate for the human dopamine transporter: the cationic or the uncharged species?

7 January 2021

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Role of protein kinase C and second messengers in regulation of the norepinephrine transporter

7 January 2021

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Molecular cloning and functional expression of the mouse dopamine transporter

7 January 2021

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Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium

7 January 2021

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Aromatic-aromatic interaction: a mechanism of protein structure stabilization

7 January 2021

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External cysteine residues in the serotonin transporter

7 January 2021

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The third transmembrane domain of the serotonin transporter contains residues associated with substrate and cocaine binding

7 January 2021

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Determination of external loop topology in the serotonin transporter by site-directed chemical labeling

7 January 2021

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Permeation and gating residues in serotonin transporter

7 January 2021

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Cocaine acts as an apparent competitive inhibitor at the outward-facing conformation of the human norepinephrine transporter: kinetic analysis of inward and outward transport.

7 January 2021

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Transport-dependent accessibility of a cytoplasmic loop cysteine in the human dopamine transporter

7 January 2021

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Differential effect of structural modification of human dopamine transporter on the inward and outward transport of dopamine

7 January 2021

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Effects of serine mutations in transmembrane domain 7 of the human norepinephrine transporter on substrate binding and transport

7 January 2021

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Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp

7 January 2021

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Multisubtrate mechanism for the inward transport of dopamine by the human dopamine transporter expressed in HEK cells and its inhibition by cocaine.

7 January 2021

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A putative model of the dopamine transporter.

7 January 2021

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Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter.

7 January 2021

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Cloning and functional characterization of a cocaine-sensitive dopamine transporter

7 January 2021

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Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

7 January 2021

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The reactivity of the gamma-aminobutyric acid transporter GAT-1 toward sulfhydryl reagents is conformationally sensitive. Identification of a major target residue

7 January 2021

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Phorbol esters increase dopamine transporter phosphorylation and decrease transport Vmax

7 January 2021

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Profound neuronal plasticity in response to inactivation of the dopamine transporter

7 January 2021

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Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter

7 January 2021

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Cloning and expression of a cocaine-sensitive rat dopamine transporter

7 January 2021

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Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding

7 January 2021

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Dopamine transporter mutants selectively enhance MPP+ transport

7 January 2021

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Phorbol esters alter functions of the expressed dopamine transporter.

7 January 2021

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MPP+ toxicity and plasma membrane dopamine transporter: study using cell lines expressing the wild-type and mutant rat dopamine transporters

7 January 2021

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The dopamine transporter carboxyl-terminal tail. Truncation/substitution mutants selectively confer high affinity dopamine uptake while attenuating recognition of the ligand binding domain

7 January 2021

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Species differences in functions of dopamine transporter: paucity of MPP+ uptake and cocaine binding in bovine dopamine transporter.

7 January 2021

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Modeling of the interaction of Na+ and K+ with the binding of dopamine and [3H]WIN 35,428 to the human dopamine transporter

7 January 2021

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Dopamine transporter: transmembrane phenylalanine mutations can selectively influence dopamine uptake and cocaine analog recognition.

7 January 2021

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Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site.

7 January 2021

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Membrane trafficking regulates the activity of the human dopamine transporter

7 January 2021

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Tyrosine-533 of rat dopamine transporter: involvement in interactions with 1-methyl-4-phenylpyridinium and cocaine.

7 January 2021

1 reference

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N-linked oligosaccharides are required for cell surface expression of the norepinephrine transporter but do not influence substrate or inhibitor recognition.

7 January 2021

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The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons

7 January 2021

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Delineation of an endogenous zinc-binding site in the human dopamine transporter

7 January 2021

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Induction by low Na+ or Cl- of cocaine sensitive carrier-mediated efflux of amines from cells transfected with the cloned human catecholamine transporters

7 January 2021

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Ion dependence of carrier-mediated release in dopamine or norepinephrine transporter-transfected cells questions the hypothesis of facilitated exchange diffusion

7 January 2021

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Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter

7 January 2021

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Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression

7 January 2021

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Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants

7 January 2021

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Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA.

7 January 2021

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Carrier-mediated release, transport rates, and charge transfer induced by amphetamine, tyramine, and dopamine in mammalian cells transfected with the human dopamine transporter.

7 January 2021

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The role of external loop regions in serotonin transport. Loop scanning mutagenesis of the serotonin transporter external domain

7 January 2021

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Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants.

7 January 2021

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Structure and function of G protein-coupled receptors

7 January 2021

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A cognate dopamine transporter-like activity endogenously expressed in a COS-7 kidney-derived cell line.

7 January 2021

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The rat serotonin transporter: identification of cysteine residues important for substrate transport

7 January 2021

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Pharmacological profile of antidepressants and related compounds at human monoamine transporters

7 January 2021

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Dopamine transporter mutants, small molecules, and approaches to cocaine antagonist/dopamine transporter disinhibitor development.

7 January 2021

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Cloning of the cocaine-sensitive bovine dopamine transporter

7 January 2021

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A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs

7 January 2021

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Dopamine transporter ligand binding domains. Structural and functional properties revealed by limited proteolysis

7 January 2021

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Species- and brain region-specific dopamine transporters: immunological and glycosylation characteristics

7 January 2021

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Protein kinase C-mediated phosphorylation and functional regulation of dopamine transporters in striatal synaptosomes

7 January 2021

1 reference

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Dopamine transporter cysteine mutants: second extracellular loop cysteines are required for transporter expression.

7 January 2021

1 reference

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Molecular cloning of the mouse dopamine transporter and pharmacological comparison with the human homologue

7 January 2021

1 reference

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Translocation of dopamine and binding of 2 beta-carbomethoxy-3 beta-(4-fluorophenyl) tropane (WIN 35,428) measured under identical conditions in rat striatal synaptosomal preparations. Inhibition by various blockers.

7 January 2021

1 reference

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Regulation of the functional activity of the human dopamine transporter by protein kinase C.

7 January 2021

1 reference

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Striatal transporter for dopamine: catechol structure-activity studies and susceptibility to chemical modification.

7 January 2021

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7 January 2021

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Identifiers

DOI

10.1016/S0014-2999(00)00563-X

1 reference

30 July 2017

1 reference

PubMed ID

11033338