Phosphodiesterase 4 inhibitors and the treatment of asthma: where are we now and where do we go from here? (Q33871349)

29 July 2017

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title

Phosphodiesterase 4 inhibitors and the treatment of asthma: where are we now and where do we go from here? (English)

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29 July 2017

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Giembycz MA

1

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PubMed ID

10730545

29 July 2017

language of work or name

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1 February 2000

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29 July 2017

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29 July 2017

59

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29 July 2017

193-212

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29 July 2017

2

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https://scigraph.springernature.com/pub.10.2165/00003495-200059020-00004

29 July 2017

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cites work

Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059020-00004

Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059020-00004

Effects of nonselective and isozyme selective cyclic nucleotide phosphodiesterase inhibitors on antigen-induced cytokine gene expression in peripheral blood mononuclear cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059020-00004

Effects of theophylline and rolipram on antigen-induced airway responses in neonatally immunized rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059020-00004

Role of multiple cAMP-specific phosphodiesterase variants

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059020-00004

Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNF alpha generation from human monocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformer

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059020-00004

Theophylline therapy inhibits neutrophil and mononuclear cell chemotaxis from chronic asthmatic children

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059020-00004

The role of nuclear factor-kappa B in cytokine gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059020-00004

Expired nitric oxide and airway obstruction in asthma patients with an acute exacerbation

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059020-00004

Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by 'type IV'-selective PDE inhibitors

21 January 2018

1 reference

12 December 2020

Structure of two rat genes coding for closely related rolipram-sensitive cAMP phosphodiesterases. Multiple mRNA variants originate from alternative splicing and multiple start sites

1 reference

12 December 2020

Theophylline. A review of its potential steroid sparing effects in asthma

1 reference

12 December 2020

Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13.

1 reference

12 December 2020

Cyclic AMP-dependent regulation of lipid mediators in white cells. A unifying concept for explaining the efficacy of theophylline in asthma

1 reference

12 December 2020

Prospects for selective cyclic nucleotide phosphodiesterase inhibitors in the treatment of bronchial asthma

1 reference

12 December 2020

Trials of the bronchodilator activity of the isoenzyme-selective phosphodiesterase inhibitor AH 21-132 in healthy volunteers during a methacholine challenge test

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12 December 2020

Reduction in pulmonary hypertension and in airway resistances by enoximone (MDL 17,043) in decompensated COPD.

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12 December 2020

Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B.

1 reference

12 December 2020

Phosphodiesterase expression in human epithelial cells

1 reference

12 December 2020

Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram.

1 reference

12 December 2020

Low-dose theophylline modulates T-lymphocyte activation in allergen-challenged asthmatics

1 reference

12 December 2020

Influence of selective phosphodiesterase inhibitors on human neutrophil functions and levels of cAMP and Cai.

1 reference

12 December 2020

Regulation of distinct cyclic AMP-specific phosphodiesterase (phosphodiesterase type 4) isozymes in human monocytic cells

1 reference

12 December 2020

Phosphodiesterase isozymes: molecular targets for novel antiasthma agents

1 reference

12 December 2020

The in vivo pharmacology of CP-80, 633, a selective inhibitor of phosphodiesterase 4

1 reference

12 December 2020

Antiasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig.

1 reference

12 December 2020

A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma

1 reference

12 December 2020

Long-term oral therapy of congestive heart failure with phosphodiesterase inhibitors

1 reference

12 December 2020

The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4.

1 reference

12 December 2020

Phosphodiesterase IV inhibitors as therapy for eosinophil-induced lung injury in asthma

1 reference

12 December 2020

The N-terminal alternately spliced regions of PDE4A cAMP-specific phosphodiesterases determine intracellular targeting and regulation of catalytic activity

1 reference

12 December 2020

The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-alpha production by human mononuclear cells

1 reference

12 December 2020

Inhibition of human neutrophil degranulation by forskolin in the presence of phosphodiesterase inhibitors

1 reference

12 December 2020

Anti-inflammatory effects of low-dose oral theophylline in atopic asthma

1 reference

12 December 2020

Expression and regulation of human and rat phosphodiesterase type IV isogenes

1 reference

12 December 2020

Induction of phosphodiesterases 3B, 4A4, 4D1, 4D2, and 4D3 in Jurkat T-cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor agonists. Potential role in beta2-adrenoreceptor desensitization.

1 reference

12 December 2020

Studies on anti-allergic action of AH 21-132, a novel isozyme-selective phosphodiesterase inhibitor in airways.

1 reference

12 December 2020

Pharmacokinetics of rolipram in the rhesus and cynomolgus monkeys, the rat and the rabbit. Studies on species differences

1 reference

12 December 2020

Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)

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12 December 2020

Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD)

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12 December 2020

Multiple cyclic nucleotide phosphodiesterases

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12 December 2020

Effects of selective phosphodiesterase inhibitors on platelet-activating factor- and antigen-induced airway hyperreactivity, eosinophil accumulation, and microvascular leakage in guinea pigs.

1 reference

12 December 2020

PDE isoenzymes as targets for anti-asthma drugs

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12 December 2020

Rolipram inhibits airway microvascular leakage induced by platelet-activating factor, histamine and bradykinin in guinea-pigs

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12 December 2020

Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase

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12 December 2020

Differential inhibition of human neutrophil functions. Role of cyclic AMP-specific, cyclic GMP-insensitive phosphodiesterase

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12 December 2020

Inhibitors of phosphodiesterase IV (PDE IV) increase acid secretion in rabbit isolated gastric glands: correlation between function and interaction with a high-affinity rolipram binding site

1 reference

12 December 2020

Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart

1 reference

12 December 2020

Anti-inflammatory effects of theophylline: modulation of cytokine production

1 reference

12 December 2020

Isozyme-selective cyclic nucleotide phosphodiesterase inhibitors: biochemistry, pharmacology and therapeutic potential in asthma.

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12 December 2020

1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma

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12 December 2020

Asthma, adenosine, mast cells and theophylline

1 reference

12 December 2020

Tailoring cAMP-signalling responses through isoform multiplicity

1 reference

12 December 2020

Phosphodiesterase inhibitors: new opportunities for the treatment of asthma

1 reference

12 December 2020

Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor

1 reference

12 December 2020

Characterization of guinea-pig eosinophil phosphodiesterase activity. Assessment of its involvement in regulating superoxide generation

1 reference

12 December 2020

Regulation of interleukin-13 by type 4 cyclic nucleotide phosphodiesterase (PDE) inhibitors in allergen-specific human T lymphocyte clones

1 reference

12 December 2020

Modulation of antigen- and mitogen-induced proliferative responses of peripheral blood mononuclear cells by nonselective and isozyme selective cyclic nucleotide phosphodiesterase inhibitors

1 reference

12 December 2020

Differential effect of phosphodiesterase 4 inhibitors on the proliferation of human peripheral blood mononuclear cells from normals and subjects with atopic dermatitis

1 reference

12 December 2020

Suppression of human eosinophil respiratory burst and cyclic AMP hydrolysis by inhibitors of type IV phosphodiesterase: interaction with the beta adrenoceptor agonist albuterol

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12 December 2020

Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase

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12 December 2020

Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response

1 reference

12 December 2020

Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret

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12 December 2020

Effect of theophylline on the proportion and function of T-suppressor cells in asthmatic children

1 reference

12 December 2020

Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase

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12 December 2020

Immunomodulation by theophylline in asthma. Demonstration by withdrawal of therapy

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12 December 2020

Has the management of asthma improved?

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12 December 2020

Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: a comparative study

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12 December 2020

Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases

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12 December 2020

Effects of theophylline on inflammatory cells and cytokines in asthmatic subjects: a placebo-controlled parallel group study

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12 December 2020

PDE4 inhibition and a corticosteroid in chronically antigen exposed conscious guinea-pigs

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12 December 2020

Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils

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12 December 2020

Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A

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12 December 2020

Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst

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12 December 2020

Effects of rolipram on responses to acute and chronic antigen exposure in monkeys.

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12 December 2020

Asthma therapy for the 21st century.

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12 December 2020

Inhibition of allergen-induced lung eosinophilia by type-III and combined type III- and IV-selective phosphodiesterase inhibitors in brown-Norway rats

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12 December 2020

Tumour necrosis factor alpha-induced oxidative burst in neutrophils adherent to fibronectin: effects of cyclic AMP-elevating agents

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12 December 2020

Electrophysiology of phosphodiesterase inhibitors

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12 December 2020

Interleukin-5 production by peripheral blood mononuclear cells of asthmatic patients is suppressed by T-440: relation to phosphodiesterase inhibition

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12 December 2020

Theophylline in chronic asthma--evidence for disease-modifying properties

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12 December 2020

Effects of inhibitors of phosphodiesterase, on antigen-induced bronchial hyperreactivity in conscious sensitized guinea-pigs and airway leukocyte infiltration

1 reference

12 December 2020

Characterization of cAMP-dependent inhibition of LPS-induced TNF alpha production by rolipram, a specific phosphodiesterase IV (PDE IV) inhibitor

1 reference

12 December 2020

Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: role in regulating proliferation and the biosynthesis of interleukin-2

1 reference

12 December 2020

Effects of isozyme-selective phosphodiesterase inhibitors on eosinophil infiltration in the guinea-pig lung

1 reference

12 December 2020

Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes

1 reference

12 December 2020

Inhibitors of cyclic nucleotide phosphodiesterase isoenzymes--their potential utility in the therapy of asthma

1 reference

12 December 2020

Modulation of TNF alpha and IL-1 beta from endotoxin-stimulated monocytes by selective PDE isozyme inhibitors

1 reference

12 December 2020

The prolonged survival of human eosinophils with interleukin-5 and its inhibition by theophylline via apoptosis

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12 December 2020

Bronchodilator effect of inhaled olprinone, a phosphodiesterase 3 inhibitor, in asthmatic patients

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12 December 2020

Bronchodilator and bronchoprotective effects of cilostazol in humans in vivo

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12 December 2020

Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants

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12 December 2020

Induction of suppressor T cells in asthmatic children by theophylline treatment

1 reference

12 December 2020

A selective type 4 phosphodiesterase inhibitor, T-440, modulates intracellular cyclic AMP level and interleukin-2 production of Jurkat cells

1 reference

12 December 2020

Inhibition of PAF-induced expression of CD11b and shedding of L-selectin on human neutrophils and eosinophils by the type IV selective PDE inhibitor, rolipram

1 reference

12 December 2020

Evidence that cyclic AMP phosphodiesterase inhibitors suppress interleukin-2 release from murine splenocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformer

1 reference

12 December 2020

Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice

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12 December 2020

Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene

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12 December 2020

Brain distribution of four rat homologues of the Drosophila dunce cAMP phosphodiesterase.

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12 December 2020

Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase

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12 December 2020

Phosphodiesterase inhibitors suppress proliferation of peripheral blood mononuclear cells and interleukin-4 and -5 secretion by human T-helper type 2 cells

1 reference

12 December 2020

Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase (PDE IV) in the ferret

1 reference

12 December 2020

Phosphodiesterase inhibitors: Lily the Pink's medicinal compound for asthma?

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12 December 2020

The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform

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12 December 2020

Pharmacology, mechanisms of action and uses of selective phosphodiesterase inhibitors

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12 December 2020

Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse

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12 December 2020

The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family

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12 December 2020

Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: a diverse family of regulatory enzymes

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12 December 2020

Inhibition of antigen-induced pulmonary eosinophilia and neutrophilia by selective inhibitors of phosphodiesterase types 3 or 4 in Brown Norway rats

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12 December 2020

Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase

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12 December 2020

CD3- and CD28-dependent induction of PDE7 required for T cell activation

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12 December 2020

Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C).

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12 December 2020

Effects of isoenzyme-selective inhibitors of cyclic nucleotide phosphodiesterase on microvascular leak in guinea pig airways in vivo.

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12 December 2020

Chronic obstructive pulmonary disease: new opportunities for drug development

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12 December 2020

Prostaglandin E2 and other cyclic AMP-elevating agents modulate IL-2 and IL-2R alpha gene expression at multiple levels

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12 December 2020

Preliminary identification and role of phosphodiesterase isozymes in human basophils

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12 December 2020

Effect of selective phosphodiesterase 3 inhibition on the early and late asthmatic responses to inhaled allergen

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12 December 2020

The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions

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12 December 2020

Increased interleukin-4 production by atopic mononuclear leukocytes correlates with increased cyclic adenosine monophosphate-phosphodiesterase activity and is reversible by phosphodiesterase inhibition

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12 December 2020

Interleukin-10 does not mediate the inhibitory effect of PDE-4 inhibitors and other cAMP-elevating drugs on lipopolysaccharide-induced tumors necrosis factor-alpha generation from human peripheral blood monocytes.

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12 December 2020

Pathologic changes in blood vessels following administration of an inotropic vasodilator (ICI 153,110) to the rat

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12 December 2020

The effect of a novel orally active selective PDE4 isoenzyme inhibitor (CDP840) on allergen-induced responses in asthmatic subjects

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12 December 2020

Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase

1 reference

12 December 2020

Cyclic AMP-elevating agents down-regulate the oxidative burst induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) in adherent neutrophils

1 reference

12 December 2020

Modulation of cell adhesion molecule expression and function on human lung microvascular endothelial cells by inhibition of phosphodiesterases 3 and 4.

1 reference

12 December 2020

SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions.

1 reference

12 December 2020

Pulmonary antiallergic and bronchodilator effects of isozyme-selective phosphodiesterase inhibitors in guinea pigs.

1 reference

12 December 2020

Identification and function of cyclic nucleotide phosphodiesterase isoenzymes in airway epithelial cells

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12 December 2020

Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis

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12 December 2020

The effects of theophylline on mucosal inflammation in asthmatic airways: biopsy results

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12 December 2020

The pulmonary disposition of theophylline and its influence on human alveolar macrophage bactericidal function

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12 December 2020

Role of low Km cyclic AMP phosphodiesterase inhibition in tracheal relaxation and bronchodilation in the guinea pig

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12 December 2020

The ability of phosphodiesterase IV inhibitors to suppress superoxide production in guinea pig eosinophils is correlated with inhibition of phosphodiesterase IV catalytic activity

1 reference

12 December 2020

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

1 reference

12 December 2020

Quaternary substituted PDE IV inhibitors II: the synthesis and in vitro evaluation of a novel series of gamma-lactams

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12 December 2020

Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase

1 reference

12 December 2020

Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1)

1 reference

12 December 2020

Modulation of cytokine-induced eosinophil infiltration by phosphodiesterase inhibitors

1 reference

12 December 2020

Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae

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12 December 2020

Effects of phosphodiesterase inhibitors on human lung mast cell and basophil function

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12 December 2020

Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone

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12 December 2020

Multiple high-affinity cAMP-phosphodiesterases in human T-lymphocytes

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12 December 2020

Prevalence of asthma and hay fever in England and Wales

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12 December 2020

Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructs

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12 December 2020

Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase

1 reference

12 December 2020

Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4

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12 December 2020

Two isoforms of cGMP-inhibited cyclic nucleotide phosphodiesterases in human tissues distinguished by their responses to vesnarinone, a new cardiotonic agent

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12 December 2020

Could isoenzyme-selective phosphodiesterase inhibitors render bronchodilator therapy redundant in the treatment of bronchial asthma?

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12 December 2020

Proposal for pharmacologically distinct conformers of PDE4 cyclic AMP phosphodiesterases

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12 December 2020

The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP

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12 December 2020

Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [3H]rolipram binding

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12 December 2020

Pulmonary antiallergic and antiinflammatory effects of a novel, orally-active phosphodiesterase IV inhibitor (WAY-127093B) in guinea pigs and rats

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12 December 2020

The influence of endogenous catecholamines on the inhibitory effects of rolipram against early- and late-phase response to antigen in the guinea pig.

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12 December 2020

Trends in sales of drugs for asthma in New Zealand, Australia, and the United Kingdom, 1975-81.

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12 December 2020

Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family

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12 December 2020

Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: 'designer' changes in Vmax, stability and membrane association.

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12 December 2020

Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation

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12 December 2020

Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy

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12 December 2020

CDP840: a novel inhibitor of PDE-4.

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12 December 2020

Phosphodiesterase type 4 inhibitors, but not glucocorticoids, are more potent in suppression of cytokine secretion by mononuclear cells from atopic than nonatopic donors

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12 December 2020

Inhibition of chemotactic peptide-induced neutrophil adhesion to vascular endothelium by cAMP modulators

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12 December 2020

Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs

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12 December 2020

Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase

1 reference

12 December 2020

Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition

1 reference

12 December 2020

Theophylline--an immunomodulatory role in asthma?

1 reference

12 December 2020

Inhibition of bronchospasm and ozone-induced airway hyperresponsiveness in the guinea-pig by CDP840, a novel phosphodiesterase type 4 inhibitor

1 reference

12 December 2020

LY 186655, a phosphodiesterase inhibitor, inhibits histamine release from human basophils, lung and skin fragments

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12 December 2020

The toxicity of repeated exposures to rolipram, a type IV phosphodiesterase inhibitor, in rats

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12 December 2020

Suppression of eosinophil function by RP 73401, a potent and selective inhibitor of cyclic AMP-specific phosphodiesterase: comparison with rolipram

1 reference

12 December 2020

Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase

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12 December 2020

Bronchodilatory effect of inhaled zardaverine, a phosphodiesterase III and IV inhibitor, in patients with asthma

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12 December 2020

Effects of the mixed phosphodiesterase III/IV inhibitor, zardaverine, on airway function in patients with chronic airflow obstruction

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12 December 2020

Influence of isoproterenol and phosphodiesterase inhibitors on platelet-activating factor biosynthesis in the human neutrophil

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12 December 2020

Recent progress in understanding the hormonal regulation of phosphodiesterases.

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12 December 2020

Type 4 phosphodiesterase inhibitors have clinical and in vitro anti-inflammatory effects in atopic dermatitis

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12 December 2020

Need for theophylline in severe steroid-requiring asthmatics

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12 December 2020

Cytokine production by phytohemagglutinin-stimulated human blood cells: effects of corticosteroids, T cell immunosuppressants and phosphodiesterase IV inhibitors

1 reference

12 December 2020

A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA

1 reference

12 December 2020

Phosphodiesterase inhibition by Ro 20-1724 reduces hyper-IgE synthesis by atopic dermatitis cells in vitro

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12 December 2020

Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

1 reference

12 December 2020

10.2165/00003495-200059020-00004

Identifiers

DOI

1 reference

PubMed ID

10730545

Dimensions Publication ID

29 July 2017

0 references

1 reference

PubMed ID

10730545