Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization (Q35028704)

scientific article

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English	Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization	scientific article

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scholarly article

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stated in

Europe PubMed Central

5 August 2017

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Europe PubMed Central

title

Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization (English)

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stated in

Europe PubMed Central

5 August 2017

G protein-coupled receptor

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2

Robert J Lefkowitz

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stated in

Europe PubMed Central

5 August 2017

Trudy A Kohout

1

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stated in

Europe PubMed Central

5 August 2017

1 January 2003

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stated in

Europe PubMed Central

5 August 2017

Molecular Pharmacology

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stated in

Europe PubMed Central

5 August 2017

63

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Europe PubMed Central

5 August 2017

9-18

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stated in

Europe PubMed Central

5 August 2017

1

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Europe PubMed Central

5 August 2017

Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart

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Regulation of G protein-coupled receptor kinase subtypes by calcium sensor proteins.

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Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases

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Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79.

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Inhibition of rhodopsin kinase by recoverin. Further evidence for a negative feedback system in phototransduction

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Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice

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Degradation of the G protein-coupled receptor kinase 2 by the proteasome pathway

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beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation

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Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart

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Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins

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Characterization of the G Protein-coupled Receptor Kinase GRK4

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G protein-coupled receptor kinases

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Adjuvant arthritis induces down-regulation of G protein-coupled receptor kinases in the immune system.

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Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor

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Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2

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Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization

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Localization of the sites for Ca2+-binding proteins on G protein-coupled receptor kinases.

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Mammalian RGS proteins: barbarians at the gate

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Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments

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Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor

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Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase

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Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice

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Beta-arrestin- and c-Src-dependent degradation of G-protein-coupled receptor kinase 2

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Characterization of G protein-coupled receptor regulation in antisense mRNA-expressing cells with reduced arrestin levels

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PDE4 cAMP-specific phosphodiesterases

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Heterotrimeric G proteins: organizers of transmembrane signals

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c-Src tyrosine kinase binds the beta 2-adrenergic receptor via phospho-Tyr-350, phosphorylates G-protein-linked receptor kinase 2, and mediates agonist-induced receptor desensitization

1 reference

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Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases

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Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence

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Regulation of rhodopsin phosphorylation by a family of neuronal calcium sensors

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Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function

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Prolonged photoresponses in transgenic mouse rods lacking arrestin

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Agonist-dependent phosphorylation of the G protein-coupled receptor kinase 2 (GRK2) by Src tyrosine kinase

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Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.

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Regulation of G protein-coupled receptor kinases by calmodulin and localization of the calmodulin binding domain

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Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling

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Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors

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Inhibition of G protein-coupled receptor kinase subtypes by Ca2+/calmodulin

1 reference

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Ca(2+)-dependent interaction of recoverin with rhodopsin kinase.

1 reference

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Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation

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Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid

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Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq.

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A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor

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G protein-coupled receptor kinase 4 gene variants in human essential hypertension

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The role of receptor kinases and arrestins in G protein-coupled receptor regulation

1 reference

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G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization.

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Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms

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Phosphorylation-independent regulation of metabotropic glutamate receptor signaling by G protein-coupled receptor kinase 2.

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Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins

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Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses

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Phosphorylation and activation of beta-adrenergic receptor kinase by protein kinase C.

1 reference

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Arresting developments in heptahelical receptor signaling and regulation

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The formation of stable rhodopsin-arrestin complexes induces apoptosis and photoreceptor cell degeneration.

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Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C.

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Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity

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Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs).

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Regulation of the G protein-coupled receptor kinase GRK5 by protein kinase C.

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Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

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Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1

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Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure

1 reference

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Enhanced morphine analgesia in mice lacking beta-arrestin 2

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Molecular tinkering of G protein-coupled receptors: an evolutionary success

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Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase

1 reference

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Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein)

1 reference

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Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies

1 reference

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beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation

1 reference

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Agonist-dependent modulation of G protein-coupled receptor kinase 2 by mitogen-activated protein kinases

1 reference

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A novel subtype of G-protein-coupled receptor kinase, GRK7, in teleost cone photoreceptors.

1 reference

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Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases.

1 reference

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Identifiers

DOI

10.1124/MOL.63.1.9

1 reference

stated in

Europe PubMed Central

5 August 2017

1 reference

Europe PubMed Central

PubMed ID

12488531

retrieved

5 August 2017

ResearchGate publication ID

10984510

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Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization (Q35028704)

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Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization (Q35028704)

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