Androgens negatively regulate forkhead transcription factor FKHR (FOXO1) through a proteolytic mechanism in prostate cancer cells (Q40598904)

21 September 2017

Androgens negatively regulate forkhead transcription factor FKHR (FOXO1) through a proteolytic mechanism in prostate cancer cells (English)

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21 September 2017

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Haojie Huang

1

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21 September 2017

David C Muddiman

series ordinal

2

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21 September 2017

Donald J Tindall

series ordinal

3

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21 September 2017

language of work or name

English

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publication date

15 January 2004

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Journal of Biological Chemistry

21 September 2017

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21 September 2017

279

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21 September 2017

13866-13877

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21 September 2017

14

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314143200

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314143200

Phosphorylation of the PTEN tail regulates protein stability and function

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314143200

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314143200

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Forkhead transcription factors contribute to execution of the mitotic programme in mammals

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314143200

DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Negative regulation of the forkhead transcription factor FKHR by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Transcriptional regulation of the human FasL promoter-enhancer region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Establishment and characterization of an immortalized but non-transformed human prostate epithelial cell line: BPH-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Proteasome inhibitors: valuable new tools for cell biologists

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Inducible nitric-oxide synthase is regulated by the proteasome degradation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Proteasome inhibitors: from research tools to drug candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Cell-free degradation of p27(kip1), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

"Decoy" of androgen-responsive element induces apoptosis in LNCaP cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Resistance to apoptosis and up regulation of Bcl-2 in benign prostatic hyperplasia after androgen deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Antagonism between PTEN/MMAC1/TEP-1 and androgen receptor in growth and apoptosis of prostatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

In vivo degradation of N-myc in neuroblastoma cells is mediated by the 26S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

Regulation of cell survival and proliferation by the FOXO (Forkhead box, class O) subfamily of Forkhead transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314143200

21 January 2018

Identifiers

DOI

10.1074/JBC.M314143200

1 reference

21 September 2017

1 reference